TTF-1 甲狀腺轉錄因子1（克隆號SPT24）

廣州健侖生物科技有限公司

TTF-1表達于甲狀腺腺上皮和肺上皮細胞中。肺腫瘤研究發(fā)現(xiàn)，大多數(shù)肺小細胞癌、肺腺癌、小部分未分化大細胞肺癌和非典型類癌、少數(shù)典型類癌表達TTF-1，而肺鱗癌不表達。在甲狀腺乳頭狀腺癌中TTF-1也呈陽性，而TTF-1在其它組織均陰性表達。因此，TTF-1可用來研究肺腺癌和鱗癌，并有助于肺腺癌轉移至肺外部位的研究。

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TTF-1 甲狀腺轉錄因子1（克隆號SPT24）

【產(chǎn)品介紹】

細胞定位：細胞核/細胞漿

克隆號：SPT24

同型：IgG

適用組織：石蠟/冰凍

陽性對照：甲狀腺乳頭瘤/肺腺癌/肝癌

抗原修復：熱修復（EDTA）

抗體孵育時間：30-60min

TTF-1

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

一旦獲得被研究人員稱之為“抗原抗體者”(因為其具有攻擊和摧毀癌細胞的能力)的細胞，t細胞被輸回到病人體內進行繁殖并攻擊癌細胞。此外因為CAR抗原可以接受控制，研究人員讓細胞快速繁殖，宛如可以大規(guī)模殺死癌細胞的“抗原抗體者細胞*”。事實上試驗顯示，一個植入細胞可以在病人身上繁殖出1萬個新細胞。
報道稱，到目前為止，參與試驗的19名患者癥狀得到緩解，其中15名患者僅使用了這一種療法，包括一名9歲兒童，他是兩年前*個接受CTL019療法的病人。所有接受CTL019細胞的患者在接受細胞輸入幾天后都出現(xiàn)了細胞因子釋放綜合征，這是經(jīng)過修改的細胞在患者體內繁殖和攻擊腫瘤細胞的標記，病人癥狀輕重各有不同，表現(xiàn)為流感、高熱、抗原抗體、肌肉疼痛、低血壓和呼吸困難等，但經(jīng)過配合治療zui后這些癥狀在所抗原抗體人身上都會消失。與此同時，那些ALL病癥*消除的患者，他們體內同樣帶有CD19蛋白的非腫瘤正常B細胞也隨著腫瘤被一起清除了。研究人員指出，接受CTL019療法后正常B細胞持續(xù)缺失說明基因改良T細胞在持續(xù)活動，相信它們可以起到類似于預防腫瘤復發(fā)的長期疫苗的作用。

Once cells are known by researchers as "antigen-antibodies" (because of their ability to attack and destroy cancer cells), the t-cells are returned to the patient's body to multiply and attack the cancer cells. In addition, because CAR antigens are under control, researchers are able to multiply cells quickly, just like the "army of antigen-antibody cells" that kill cancer cells on a large scale. In fact, experiments show that one implanted cell produces 10,000 new cells in the patient.
To date, the 19 patients who participated in the trial were relieved of symptoms, 15 of whom used this therapy alone, including a 9-year-old child who was the first patient to receive CTL019 therapy two years earlier. All patients who received CTL019 cells developed cytokine release syndrome a few days after receiving the cell input, a marker of a modified cell that multiplied and attacked the tumor cells in the patient. The patient's symptoms varied in severity, manifested as flu, Fever, antigen and antibody, muscle pain, hypotension and dyspnea, but after the treatment of these symptoms in the final anti-human antibodies will disappear. In the meantime, patients with complete elimination of ALL disease also have non-tumor-normal B cells that also carry CD19 protein in their body cleared with the tumor. The researchers pointed out that the continued absence of normal B cells following CTL019 therapy suggests that the genetically modified T cells are continuously active, believing they can act as long-term vaccines that prevent tumor recurrence.