PCNA 增殖細(xì)胞核抗原? 

廣州健侖生物科技有限公司

PCNA 是和細(xì)胞周期相關(guān)的36kD的核蛋白，是細(xì)胞DNA合成所必需的蛋白。此抗體可作為細(xì)胞增殖指數(shù)的主要參考依據(jù)，用于研究惡性腫瘤的細(xì)胞增殖和判斷其惡性度，對(duì)腫瘤的治療及預(yù)后的研究有一定的意義。

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PCNA 增殖細(xì)胞核抗原?? 

【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞核

克隆號(hào)：PC10

適用組織：石蠟/冰凍

陽性對(duì)照：扁桃體

抗原修復(fù)：熱修復(fù)（檸檬酸）

抗體孵育時(shí)間：30-60min

PCNA

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【公司名稱】 廣州健侖生物科技有限公司
【市場(chǎng)部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

有上皮腫瘤細(xì)胞核SIP1染色陽性的腫瘤更晚期。有更多的淋巴結(jié)轉(zhuǎn)移。內(nèi)皮細(xì)胞中表達(dá)SNAI1預(yù)示患者存活率降低，腫瘤大小增加。而基質(zhì)細(xì)胞TWIST表達(dá)與高復(fù)發(fā)風(fēng)險(xiǎn)有。
病人和醫(yī)生往往不知道手術(shù)切除癌變組織后是否很成功，直到手術(shù)幾個(gè)月后再進(jìn)行掃描時(shí)才能知道?，F(xiàn)在，一種新的納米顆粒可以更早地顯示患者在手術(shù)后是否成功切除了全部癌變組織。
這種納米顆粒被稱為納米耀斑(nanoflares)。在實(shí)驗(yàn)時(shí)，顆粒會(huì)依附于血液樣品中的每一個(gè)單獨(dú)的癌細(xì)胞上，然后會(huì)發(fā)光。通過激光的輔助可以檢測(cè)到癌細(xì)胞或?qū)ζ浞诸?。因?yàn)橛泻芏嗖煌愋偷陌┘?xì)胞，其中有一些癌細(xì)胞遠(yuǎn)遠(yuǎn)比其他的更加致命，通過使用這個(gè)技術(shù)可以檢測(cè)到這些更致命癌細(xì)胞并采集它們，因?yàn)檫@些細(xì)胞在采集之后還可以在培養(yǎng)皿中進(jìn)行培養(yǎng)，用納米顆粒還可以在給病人真正治療前，更容易地測(cè)試一些潛在的治療方案。
研究人員表明，目前該納米顆?？蓹z測(cè)小鼠不同類型的抗原抗體癌細(xì)胞。他們還表明，納米顆粒在添加進(jìn)人類血液后也能識(shí)別出抗原抗體癌細(xì)胞。他們下一步是確定該顆粒能否從患者體內(nèi)提取的血液樣本中發(fā)現(xiàn)癌細(xì)胞。

SIP1-positive tumors with epithelial tumor nuclei are more advanced. There are more lymph node metastases. The expression of SNAI1 in endothelial cells predicts a decrease in patient survival and an increase in tumor size. The expression of stromal cells TWIST is associated with a high risk of recurrence.
Patients and doctors often do not know whether successful surgical resection of cancerous tissue is successful until a few months after the surgery before scanning. Now, a new nanoparticle can show earlier whether the patient successfully resected all cancerous tissue after surgery.
This type of nanoparticle is called nanoflares. During the experiment, the particles attach to each individual cancer cell in the blood sample and then glow. Cancer cells can be detected or classified by the help of laser. Because there are many different types of cancer cells, some of which are far more lethal than others, these more deadly cancer cells can be detected and harvested using this technique because they can also be collected in a Petri dish For incubation, using nanoparticles also makes it easier to test some potential treatment options before actually treating the patient.
Researchers have shown that at present the nanoparticles can detect different types of antigen in mice antibody cancer cells. They also show that nanoparticles can also recognize antigen-presenting cancer cells when added to human blood. Their next step is to determine if the particle can find cancer cells in blood samples taken from the patient's body.