詳細(xì)介紹
P63蛋白(克隆號4A4)
廣州健侖生物科技有限公司
p63是抑癌基因p53的同源性基因,定位于染色體3q27-28,編碼6種以上異構(gòu)體。在許多上皮組織的基底層中高表達(dá)。乳腺中表達(dá)于所有正常乳腺的肌上皮細(xì)胞,部分表達(dá)于導(dǎo)管增生細(xì)胞,極少量表達(dá)于原位乳腺癌,在浸潤性導(dǎo)管癌中無表達(dá)。p63 的缺失表達(dá)與乳腺導(dǎo)管癌的進(jìn)程可能有一定的相關(guān)性。因此,p63 免疫組化染色對于乳腺浸潤性導(dǎo)管癌、原位導(dǎo)管癌以及少量可疑的導(dǎo)管增生性損傷等疾病的研究有幫助。p63也是一種前列腺基底細(xì)胞的參考依據(jù),但在絕大多前列腺腫瘤中不表達(dá)。該抗體主要用于乳腺、前列腺良惡性病變的研究。
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P63蛋白(克隆號4A4)
【產(chǎn)品介紹】
細(xì)胞定位:細(xì)胞核
克隆號:4A4
同型:IgG
適用組織:石蠟/冰凍
陽性對照:前列腺/乳腺/肺鱗癌
抗原修復(fù):熱修復(fù)(EDTA)
抗體孵育時間:30-60min
產(chǎn)品編號 | 抗體名稱 | 克隆型別 |
OB181 | NeuN(神經(jīng)元特異核蛋白) | A60 |
OB182 | NF(神經(jīng)絲蛋白) | 2F11 |
OB183 | NGFR試劑 | MRQ-21 |
OB184 | nm23(腫瘤轉(zhuǎn)移抑制基因蛋白) | 37.6 |
OB185 | NSE(神經(jīng)元特異性烯醇化酶) | E27 |
OB186 | OCT-2(胚胎干細(xì)胞關(guān)鍵蛋白2) | MRQ-2 |
OB187 | OCT-4(胚胎干細(xì)胞關(guān)鍵蛋白4) | MRQ-10 |
OB188 | Olig2(少突膠質(zhì)細(xì)胞轉(zhuǎn)錄因子2) | 211F1.1 |
OB189 | p120 Catenin(p120連接素) | MRQ-5 |
OB190 | P16(p16蛋白) | AbM51100-10 |
OB191 | P27kip1(細(xì)胞周期調(diào)節(jié)和腫瘤抑制因子) | SX53G8 |
OB192 | P40 (p40蛋白) | ZR8 |
OB193 | P504s( α-甲基酰基輔酶A消旋酶) | 13H4 |
OB194 | P53(p53蛋白) | DO7 |
OB195 | P57Kip2(有絲分裂抑制因子) | Kp10 |
OB196 | P63(p63蛋白) | 2B10 |
OB197 | P63(p63蛋白) | 4A4 |
OB198 | PAX-5(B細(xì)胞系特異性激活蛋白) | SP34 |
OB199 | PAX-8(轉(zhuǎn)錄因子8) | MRQ-50 |
OB200 | PCNA(增殖細(xì)胞核抗原) | PC10 |
想了解更多的產(chǎn)品及服務(wù)請掃描下方二維碼:
【公司名稱】 廣州健侖生物科技有限公司
【市場部】 歐
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【騰訊 】
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室
目前,歐盟干細(xì)胞研究的商業(yè)化應(yīng)用,主要針對人體受損細(xì)胞替代的疾病治療,包括大面積燒傷、白血病患者的血液系統(tǒng)修復(fù)和心血管系統(tǒng)醫(yī)療。正在開展干細(xì)胞直接分化成專業(yè)化功能細(xì)胞類型,進(jìn)行治療包括帕金森疾病(Parkinson’s)、中風(fēng)、心臟病和糖尿病在內(nèi)的臨床試驗。
歐盟第七研發(fā)框架計劃(FP7)和歐盟2020地平線(Horizon 2020),是歐盟層面資助干細(xì)胞研究的zui主要平臺。目前資助的干細(xì)胞研究研發(fā)創(chuàng)新項目主要包括:應(yīng)用干細(xì)胞開發(fā)神經(jīng)功能化細(xì)胞;干細(xì)胞修復(fù)中風(fēng)損傷細(xì)胞;干細(xì)胞應(yīng)用技術(shù)、工具、標(biāo)準(zhǔn)開發(fā)及社會文化普及;干細(xì)胞毒理學(xué)篩選技術(shù);干細(xì)胞融合技術(shù)治療帕金森疾病;和負(fù)責(zé)任的干細(xì)胞科研與創(chuàng)新等等。
據(jù)來自東芬蘭大學(xué)的一項研究證實:SIP1蛋白在咽部鱗狀細(xì)胞癌腫瘤中的表達(dá)往往預(yù)示一種晚期的腫瘤分期,一種復(fù)發(fā)高危及預(yù)后不良。
基于該結(jié)果提示,SIP1或是可用于臨床使用的潛在預(yù)后因素,幫助預(yù)測哪些患者有更侵襲性的腫瘤行為,以確定是否需要更密集的治療。
雖然咽部鱗狀細(xì)胞癌(pharyngeal squamous Cell carcinoma, PSCC)是一個比較罕見的疾病,但在過去的三十年它的發(fā)病率一直在增加。
在所有頭頸部鱗狀細(xì)胞癌中,咽部鱗狀細(xì)胞癌是預(yù)后zui差的一種。盡管多式療法聯(lián)用的可用性,但預(yù)后并沒有得到任何顯著改善。
Currently, the commercialization of EU stem cell research is focused on the treatment of diseases that are replaced by damaged cells in humans, including extensive burns, blood system repair in patients with leukemia, and cardiovascular system medicine. Direct differentiation of stem cells into specialized functional cell types is underway for the treatment of clinical trials including Parkinson's, stroke, heart disease and diabetes.
The EU's FP7 and EU 2020 Horizon 2020 are the main platforms for funding stem cell research at the EU level. Stem cell research and development currently funded innovative projects include: the application of stem cells to develop neurofunctional cells; stem cells repair stroke injury cells; stem cell technology, tools, standard development and social and cultural popularization; stem cell toxicology screening technology; stem cell fusion technology for Parkinson Disease; and responsible stem cell research and innovation and more.
According to a study from the University of Eastern Finland, the expression of SIP1 protein in pharyngeal squamous cell carcinoma tumors often indicates a late stage of the tumor, a high recurrence rate and a poor prognosis.
Based on this result, SIP1 is either a potential prognostic factor for clinical use, helping to predict which patients have more aggressive tumor behavior to determine if more intensive treatment is needed.
Although pharyngeal squamous cell carcinoma (PSCC) is a relatively rare disease, its incidence has been increasing over the past three decades.
In all head and neck squamous cell carcinoma, pharyngeal squamous cell carcinoma is the worst prognosis. Despite the availability of multi-modality therapy, the prognosis has not seen any significant improvement.