Myosin,Smooth Muscle 肌球蛋白重鏈

廣州健侖生物科技有限公司

平滑肌肌球蛋白重鏈?zhǔn)欠肿恿繛?00kDa 的多肽，是六聚肌球蛋白的結(jié)構(gòu)成分。主要用于研究血管和內(nèi)臟平滑肌細(xì)胞以及肌上皮細(xì)胞，被認(rèn)為是平滑肌較為特異和可靠的參考依據(jù)，有助于間葉腫瘤的研究和分類，也可用于乳腺肌上皮細(xì)胞的檢測，有助于原位癌和浸潤癌的區(qū)別研究。

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Myosin,Smooth Muscle 肌球蛋白重鏈

【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞漿

克隆號(hào)：SMMS-1

同型：IgG

適用組織：石蠟/冰凍

陽性對(duì)照：骨骼肌

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時(shí)間：30-60min

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

巨噬細(xì)胞是我們機(jī)體中強(qiáng)大的“吃豆小精靈”，其可以吞咽細(xì)胞殘?jiān)安≡w來保護(hù)機(jī)體健康，近日，一篇刊登在雜志The Journal of Cell BioLogy上的研究論文中，來自威斯康辛-邁迪遜大學(xué)大學(xué)的研究人員揭示了巨噬細(xì)胞如何通過誘導(dǎo)中性白細(xì)胞，使其離開機(jī)體損傷的組織進(jìn)而幫助治療炎癥。
中性粒細(xì)胞是機(jī)體中的“*急救者”，其可以被名為活性氧激活的蛋白激酶所吸引到患處，當(dāng)中性粒細(xì)胞完成工作后，炎癥就會(huì)通過細(xì)胞抗原抗體或凋亡的方式被部分治療，隨后殘留的中性粒細(xì)胞就會(huì)被巨噬細(xì)胞所吞噬;但中性粒細(xì)胞可以通過一種逆向遷移的方式離開機(jī)體損傷的組織，目前是否巨噬細(xì)胞可以促進(jìn)炎癥的恢復(fù)尚不明確。
這項(xiàng)研究中，研究人員利用透明的斑馬魚幼體進(jìn)行研究，結(jié)果發(fā)現(xiàn)，在被巨噬細(xì)胞吞噬前中性粒細(xì)胞會(huì)被“招募”至傷口處，但是一旦其到達(dá)傷口處，巨噬細(xì)胞就會(huì)同中性粒細(xì)胞進(jìn)行接觸，并且使其遠(yuǎn)離機(jī)體損傷組織;在缺失巨噬細(xì)胞的斑馬魚機(jī)體中中性粒細(xì)胞可以在斑馬魚患處停留很長時(shí)間。就像中性粒細(xì)胞一樣，巨噬細(xì)胞可以被活性氧和蛋白激酶信號(hào)吸引至患處，而且缺失活性氧產(chǎn)生酶類Nox2的巨噬細(xì)胞并不能遷移至傷口處，反而會(huì)誘導(dǎo)中性粒細(xì)胞離開傷口。

Smooth Muscle Myosin Heavy Chain is a polypeptide having a molecular weight of 200 kDa and is a structural component of six myosin. Mainly for the study of vascular and visceral smooth muscle cells and myoepithelial cells, is considered more specific and reliable reference for smooth muscle, contribute to the study and classification of mesenchymal tumors, but also can be used for the detection of breast myoepithelial cells, contribute to Differentiation between carcinoma in situ and invasive carcinoma.

Macrophages are the powerful "eating beans" in our body that can swallow cell debris and pathogens to protect the health of the body. Recently, a review published in a research paper published in the journal International Journal The Cell BioLogy from Wisconsin- Researchers at the University of Madison are uncovering how macrophages help treat inflammation by inducing neutrophils to leave the body's damaged tissue.
Neutrophils are the "first responders" in the body that can be attracted to the affected area by a protein kinase activated by reactive oxygen species. When neutrophils have completed their work, the inflammation passes through cellular antigenic antibodies or apoptotic The modalities are partially treated, and the remaining neutrophils are then phagocytosed by macrophages; neutrophils, however, can leave the body's damaged tissue by a reverse migration, and whether macrophages can now promote the recovery of inflammation still uncertain.
In the study, researchers used transparent zebrafish larvae to study and found that neutrophils were "recruited" to the wound before being phagocytosed by macrophages, but once they reached the wound, macrophages It will contact with neutrophils and keep it away from the body to injure the tissues. In the absence of macrophages, neutrophils may stay in the zebrafish for a long time. Like neutrophils, macrophages are attracted to reactive sites by reactive oxygen species and protein kinase signals, and macrophages that lack the active oxygen-producing enzyme Nox2 do not migrate to the wound but instead induce neutrophils to leave wound.