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全身體積描記系統(tǒng)(兔、犬)產(chǎn)品描述

全身體積描記系統(tǒng)(兔、犬)（whole-bodyplethysmograph，WBP）可以對清醒自由活動的大動物進(jìn)行肺功能及氣道反應(yīng)相關(guān)的測試，避免了創(chuàng)傷性氣管切開術(shù)及麻醉的影響，使實驗過程簡便快捷，并適合長期跟蹤研究。

塔望科技開發(fā)的全身體積描記系統(tǒng)，除了做小鼠、大鼠/豚鼠外，另外還提供大動物的測試艙，如兔子、犬、猴等。

全身體積描記系統(tǒng)(兔、犬)產(chǎn)品特點

· 適用動物：兔子、犬

· 不需要做手術(shù)，操作簡單

· 可在動物在自然狀態(tài)下呼吸的研究以及長期跟蹤實驗，適合進(jìn)行藥物初篩

· 具有藥物氣溶膠霧化模塊

· 具有自動標(biāo)定功能

· 可提供食槽，進(jìn)行長期連續(xù)監(jiān)測

· 可選配測量心電、血壓、體溫、心率等指標(biāo)，可與植入式遙測設(shè)備聯(lián)合使用

· 具有分析軟件，數(shù)據(jù)可保存至excel或txt格式

全身體積描記系統(tǒng)(兔、犬)檢測參數(shù)

Ti：吸氣時間（s）

Te：呼氣時間（s）

PIF：最大吸氣流速（ml/s）

PEF：最大呼氣流速（ml/s）

Volbal：吸氣時間/呼氣時間

F：呼吸頻率（次/min）

Vt：潮氣量（ml）

Mv：分鐘通氣量（ml）

AV：累積體積（ml）

EF50：呼出50%氣量時對應(yīng)的呼氣流速（ml/s）

EIP：吸氣峰值壓力（僅在侵入式法測量時有效）

EEP：呼氣峰值壓力（僅在侵入式法測量時有效）

TR：松弛時間

PenH：增強呼氣間歇（enhanced pause）

Rpef：相對時間

全身體積描記系統(tǒng)(兔、犬)適用領(lǐng)域

各種呼吸疾病研究，如：哮喘、肺纖維化、肺損傷、ARDS、肺癌等

安全藥理：藥物對呼吸系統(tǒng)的影響

睡眠呼吸：監(jiān)測動物低通氣、阻塞性呼吸暫停等

環(huán)境毒理：環(huán)境污染物對動物呼吸的影響

吸入式毒理：染毒物質(zhì)對呼吸系統(tǒng)的毒性影響

高原醫(yī)學(xué)：高原環(huán)境對呼吸系統(tǒng)的影響

其它需要對呼吸參數(shù)評價的場合

全身體積描記系統(tǒng)(兔、犬)型號說明

全身體積描記系統(tǒng)(兔、犬)用戶名單

全身體積描記系統(tǒng)(兔、犬)相關(guān)文獻(xiàn)

[1]Sun Lingna, Fan Mingrui, Huang Dong, Li Bingqin, Xu Ruoting, Gao Feng, Chen Yanzuo. "Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis" [J]. Biomaterials,  2021

[2]李寧, 李紅鵬, 張本炎, 張柳, 沈繼敏, 李慶云. "高脂膳食對小鼠呼吸功能和膈肌纖維的影響及其線粒體機制" [J]. 中華醫(yī)學(xué)雜志,  2021,101(36):2893-2899.

[3]Xiong Jiaying,  Zhuang Tao, Ma Yurong,  Xu Junyi, Ye Jiaqi, Ma Ru, Zhang Shuang, Liu Xin, Liu Bi-Feng, Hao Chao,  Zhang Guisen,  Chen Yin. "Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain" [J]. European Journal of Medicinal Chemistry, 2021, 226:

[4]Yumei Zhou, Haihong Zhao, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, " Anti-Inflammatory and Anti-asthmatic Effects of TMDCT Decoction in Eosinophilic Asthma Through Treg/ Th17 Balance" [J].Frontiers, 2022.819728:

[5]Yumei Zhou, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, "Plasma Metabolites and Gut Microbiota Are Associated With T cell Imbalance in BALB/c Model of Eosinophilic Asthma" [J].Frontiers, 2022. 819747:

[6]Zheng R, Yang W, WenYet al. "Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening"  [J].Cell Death Dis 13, 559 (2022)

[7]Wang W, Mu M, Zou Y, Li B, Cao H, Hu D, Tao X. "Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy"  [J].PeerJ 10:e13632

[8]Dongyi Zhu, Qian Zhang, Qinchuan Li, Guangxue Wang, Zhongliang Guo. "Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF-β1/Smad3 signaling pathway" [J].The Journal of Gene Medicine, Volume24/Issue9/September 2022/e3442

[9]Jiawen Zhou, Haiyun Chen, Qiuyi Wang, Sihan Chen, Rong Wang, Ziyang Wang, Cuicui Yang, Ao Chen, Jingyu Zhao, Zihao Zhou, Zhiyuan Mao, Guoping Zuo, Dengshun Miao, Jianliang Jin. "Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription" [J].Aging CellVolume 21, Issue 8 e13680

[10]Yapeng, LuPanpanChang, WangwangDing, JiangpeiBian, DanWang, XuetingWang, QianqianLuo, XiaomeiWu, LiZhu. "Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells" [J].European Journal of Pharmacology, Volume 929, 15 August 2022, 175137

[11]Mengjun Zhanga, Huiyang Jiang, Lan Wu,  Haoyu Lu, Hriday Bera, Xing Zhao, Xiong Guo, Xulu Liu, Dongmei Cun, Mingshi Yang. "Airway epithelial cell-specific delivery of lipid nanoparticles loading siRNA for asthma treatment" [J]. Journal of Controlled Release, Volume 352

[12]Xue Lu, Zhu-Xia Tan, Wen-Jing Wang, Ping Zhan, Yan Wang, Lin Fu, Lan Gao, Hui. Zhao, Hua Wang, De-Xiang Xu. "Juvenile arsenic exposure aggravates goblet cell hyperplasia and airway mucus secretion in ovalbumin-sensitized mice" [J]. Environmental Pollution, Volume 315, 120462

[13]Gu W, Lei J., Zhu, H. et al. Effect of the BMPR-II-SMAD3/MRTF pathway on proliferation and migration of ASMCs and the mechanism in asthma [J].Mol Biol Rep 49, 9283–9296 (2022).

[14]Hu M, Yang J, Xu Y, Liu J. MDH1 and MDH2 Promote Cell Viability of Primary AT2 Cells by Increasing Glucose Uptake. Computational and Mathematical Methods in Medicine  [J]. Hindawi Computational and Mathematical Methods in Medicine/Volume 2022, Article ID 2023500, 15 pages

[15]WenJing Wang , Xue Lu , Zhao Li , Kun Peng , Ping Zhan , Lin Fu , Yan Wang , Hui Zhao , Hua Wang , De-Xiang Xu , Zhu-Xia Tan."Early-life cadmium exposure elevates susceptibility to allergic asthma in ovalbumin-sensitized and challenged mice"[J] Ecotoxicology and Environmental Safety 255 (2023) 114799

[16]Zhou Y, Hu L, Zhang H, Zhang H, Liu J, Zhao X, Wang J, Wang Q."Guominkang formula alleviate inflammation in eosinophilic asthma by regulating immune balance of Th1/2 and Treg/Th17 cells."[J].Frontiers in Pharmacology, 14 Oct 2022, 13:978421

[17]Bao XC, Wang N, Xu J, Ma J and Fang Y-Q (2023) “Effects of different simulated submarine escape depths by free ascent in animal models. “[J]Front. Physiol. 14:1107782.

[18]Haiyun Chen, Qiuyi Wang, Jie Li, Yuan Li, Ao Chen, Jiawen Zhou, Jingyu Zhao, Zhiyuan Mao, Zihao Zhou, Yue Wang, Rong Wan, Qing Li, Yongjie Zhang, Runqiu Jiang,Dengshun Miao, Jianliang Jin, “IFN Transcribed by IRF1 in CD4 + Effector Memory T Cells Promotes Senescence-Associated Pulmonary Fibrosis" [J]. Aging and Disease, DOI: 10.14336/AD.2023.0320

[19]崔淦，李琦，舒方方，王汛江，李亞娟，楊莉，王崢濤，丁麗麗. "三七總皂苷通過抑制 NF-κB 轉(zhuǎn)錄活性改善 LPS 誘導(dǎo)小鼠急性肺損傷的研究". [J]. 藥學(xué)學(xué)報. DOI： 10.16438/j.0513-4870.2022-0591

[20]IL-1β promotes IL-17A production of ILC3s to aggravate neutrophilic airway inflammation in mice Dan Yang, Yi'na Li, Ting Liu, Ling Yang, Lixiu He, Tingxuan Huang, Lanlan Zhang, Jian Luo, Chuntao Liu 。First published: 29 March 2023 13644   Jian Luo and Chuntao Liu contributed equally to this study.

[21]Meihao Peng, Jintao Li, Jie Zhou, Bowen Zhang, Jiaqing Liao, Di Yang, Yu Wang, Yixi Yang, Rui Li, Xue Tang, Qiuxia Lu, Qi Zhao,Total alkaloids of Fritillaria unibracteata var. wabuensis bulbus ameliorate chronic asthma via the TRPV1/Ca2+/NFAT pathway,Phytomedicine,2023,154946,ISSN 0944-7113,2023.154946.

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[23]Xiaoqi Hu, Jingran Su, Mo Chen, Yikun Tu, Chunyan Wu, Xue Cao, Xinyi Yuan, Fang Zhang, Wenjun Ding,Macrophage-derived exosomal TNF-α promotes pulmonary surfactant protein expression in PM2.5-induced acute lung injury,Science of The Total Environment,Volume 892,2023,164732,ISSN 0048-9697,2023.164732.

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[25]Biological Hyperthermia-Inducing Nanoparticles for Specific Remodeling of the Extracellular Matrix Microenvironment Enhance Pro-Apoptotic Therapy in Fibrosis。Jinru Zhang, Keqin Ji, Yuanmeng Ning, Lingna Sun, Mingrui Fan, Chunjie Shu, Ziqi Zhang, Tianyu Tu, Jingyun Cao, Feng Gao, and Yanzuo Chen  ACS Nano 2023 17 (11), 10113-10128   DOI: 10.1021/acsnano.2c12831

[26]Yize Yin,Chaohui Mu,Jiahui Wang,Yixuan Wang, Wenmin Hu,Wenjing Zhu,Xinjuan Yu,Wanming Hao,Yuxin Zheng, Qinghai Li, Wei Han. CXCL17 Attenuates Diesel Exhaust Emissions Exposure-Induced Lung Damage by Regulating Macrophage Function,[J]2023-07-26,DOI: 10.3390/toxics11080646

[27]Gao-Xiang Wang,Jie Zhou,You-Mou Chen,Liang-Dong Xu,Shan-Ming Tao,Jia Ma,Ye-Han Sun,Ming-Sheng Wu,Zheng-Wei Chen,Yong-Fu Zhu,Ming-Ran Xie,Mechanism of electroacupuncture at acupoints of the lung meridian through PKA/PKC regulation of TRPV1 in chronic cough after lung surgery in guinea pigs,[J]PMC 2023 Apr 28; 15(4): 1848–1860.DOI:10.21037/jtd-23-409

[28]Yang Liu, Amei Tang, Ming Liu, Changjun Xu, Feng Cao, Changfu Yang,Tuberostemonine may enhance the function of the SLC7A11/glutamate antiporter to restrain the ferroptosis to alleviate pulmonary fibrosis,[J]Journal of Ethnopharmacolog，2023-08-01 ,DOI:10.1016/j.jep.2023.116983

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