詳細(xì)介紹
GS 谷氨酰胺合成酶(鼠單克隆抗體)
廣州健侖生物科技有限公司
在哺乳動(dòng)物肝臟中,谷氨酰胺合成酶(GS)催化谷氨酸鹽和氨合成谷氨酰胺。谷氨酰胺,作為GS活性的zui終產(chǎn)物,是腫瘤細(xì)胞能源的主要來(lái)源。研究肝癌發(fā)生發(fā)現(xiàn),GS陽(yáng)性的腫瘤細(xì)胞被認(rèn)為是來(lái)源于GS陽(yáng)性的肝細(xì)胞。在正常肝臟,GS主要在圍繞門脈的肝細(xì)胞表達(dá),很少累及到中間和周圍的細(xì)胞,但在肝細(xì)胞肝癌時(shí),大多數(shù)的腫瘤細(xì)胞都有彌散性表達(dá)。在肝細(xì)胞的非惡性病變,如退行性結(jié)節(jié),其表達(dá)陽(yáng)性率低于50%,而早前肝癌和分化好的肝癌其表達(dá)陽(yáng)性率超過(guò)60%。所以,彌撒性陽(yáng)性表達(dá)與陰性或局灶性表達(dá)相比,前者有可能是早期或分化好的肝細(xì)胞肝癌。
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GS 谷氨酰胺合成酶(鼠單克隆抗體)
【產(chǎn)品介紹】
細(xì)胞定位:細(xì)胞漿
克隆號(hào):GS-6
同型:IgG2a
適用組織:石蠟/冰凍
陽(yáng)性對(duì)照:肝細(xì)胞癌
抗原修復(fù):熱修復(fù)
抗體孵育時(shí)間:30-60min
產(chǎn)品編號(hào) | 抗體名稱 | 克隆型別 |
OB108 | ERCC1(人切除修復(fù)交叉互補(bǔ)基因1) | SP68 |
OB109 | ERG | EP111 |
OB110 | Factor Ⅷ(第八因子相關(guān)抗原) | polyclonal |
OB111 | Factor ⅩⅢa(第十三因子a) | EP3372 |
OB112 | FSH(卵泡刺激素) | polyclonal |
OB113 | Galectin-3(半乳糖凝集素-3) | 9C4 |
OB114 | GATA3(心肌轉(zhuǎn)錄因子3) | L50-823 |
OB115 | GCDFP-15(巨囊性病液體蛋白15) | EP1582Y |
OB116 | GFAP(膠質(zhì)纖維酸性蛋白) | EP672Y |
OB117 | GH(生長(zhǎng)激素) | polyclonal |
OB118 | Glucagon(胰高血糖素) | polyclonal |
OB119 | GLUT1(葡萄糖轉(zhuǎn)化酶) | polyclonal |
OB120 | Glycophorin A(血型糖蛋白A)或CD235a | GA-R2&HIR2 |
OB121 | Glypican-3(磷脂酰肌醇蛋白聚糖3) | 1G12 |
OB122 | Granzyme B(粒酶B) | polyclonal |
OB123 | GS(谷氨酰胺合成酶) | GS-6 |
GS 谷氨酰胺合成酶(鼠單克隆抗體)
想了解更多的產(chǎn)品及服務(wù)請(qǐng)掃描下方二維碼:
【公司名稱】 廣州健侖生物科技有限公司
【市場(chǎng)部】 歐
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【騰訊 】
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室
成效顯著
接下來(lái),研究小組著眼于“這些藥物如何影響小鼠的健康和衰老”。Niedernhofer的加速衰老動(dòng)物模型被廣泛用于本研究當(dāng)中,他說(shuō):“在動(dòng)物模型中,這些化合物能改善心血管功能和運(yùn)動(dòng)耐力,減少骨質(zhì)疏松和脆弱,并延長(zhǎng)健康壽命。值得注意的是,在某些情況下,這些藥物只用僅僅一個(gè)療程就能達(dá)到療效。”
在老年小鼠中,通過(guò)五天的單次劑量藥物,心血管功能得到了改善。單劑量的藥物組合,可使接受癌癥放射治療的小鼠的運(yùn)動(dòng)能力得以提高。在藥物治療后,藥效能持續(xù)至少七個(gè)月。周期性地給加速衰老小鼠模型服用該藥物,可延長(zhǎng)動(dòng)物的健康壽命,緩解與年齡有關(guān)的癥狀、脊柱退行性變和骨質(zhì)疏松癥。
作者警告說(shuō),在人類使用前,還需要更多的測(cè)試。他們也指出,該研究中的兩種藥物可能有副作用,至少在長(zhǎng)期治療時(shí)。
然而,研究人員仍然對(duì)他們這一研究結(jié)果的潛力持樂(lè)觀態(tài)度。Robbins說(shuō):“衰老與許多疾病和病癥有關(guān),所以這些化合物以及類似的化合物,可能有很多的應(yīng)用價(jià)值。同時(shí),我們希望用senolytic藥物治療來(lái)清除受損細(xì)胞,這將是罕見(jiàn)的,能夠減少副作用的機(jī)會(huì)。”
Significant effect
Next, the team looked at "how these drugs affect the health and aging of mice." Niedernhofer's accelerated aging animal model is widely used in this study, he said: "In animal models, these compounds can improve cardiovascular function and exercise tolerance, reduce osteoporosis and vulnerability, and extend the healthy life .It is noteworthy that In some cases, these drugs can be effective in just one course of treatment. "
In older mice, cardiovascular function improved with a single five-day dose of medication. A single dose of the drug combination can increase the motor ability of mice receiving radiation treatment of cancer. After the drug treatment, the efficacy lasted at least seven months. Periodic administration of the drug to accelerated aging mouse models prolongs the healthy life of the animal and alleviates age-related symptoms, spinal degeneration and osteoporosis.
The authors warn that more tests are needed before humans can use them. They also point out that the two drugs in the study may have side effects, at least during long-term treatment.
However, researchers are still optimistic about the potential of their findings. "Aging can be associated with many diseases and conditions, so these and similar compounds may have a lot of value," Robbins said In the meantime, we hope that using senolytic medications to remove damaged cells will be rare and reduce side effects Opportunity."
In mammalian liver, glutamine synthase (GS) catalyzes the synthesis of glutamine and ammonia. Glutamine, the end product of GS activity, is a major source of energy for tumor cells. Study found that liver cancer, GS positive tumor cells are considered to be derived from GS-positive hepatocytes. In normal liver, GS is mainly expressed in hepatocytes around the portal vein, rarely involving the middle and surrounding cells, but most of the tumor cells have diffuse expression in hepatocellular carcinoma. In non-malignant liver cells, such as degenerative nodules, the positive expression rate of less than 50%, while the early liver cancer and well-differentiated liver cancer its positive rate of more than 60%. Therefore, the mass-positive expression compared with negative or focal expression, the former may be early or well-differentiated hepatocellular carcinoma.