Vanillotoxin 3(VaTx3)

選擇性激活哺乳動(dòng)物辣椒素受體（TRPV1）

Vanillotoxin 3: Toxin description

Vanillotoxin-3 (VaTx3) has been isolated from the venom of Psalmopoeus cambridgei, a West Indies tarantula. It is a 34 amino acids peptide with three disulfide bridges with an ICK motif. It selectively activates mammalian TRPV1 (capsaicin receptor), a non-selective cation channel expressed by sensory neurons of the pain pathway with an EC₅₀ value of 0.45 ± 0.04 µM. It is more potent than VaTx1 (20-fold) and VaTx2 (2-fold), two other analogues of VaTx3 with closely related sequences and isolated from the same venom. VaTx3 probably interacts with distinct regions of the channel than capsaicin. VaTx3 does not affect TRPV2, TRPV3, TRPV4, TRPA1, TRPM8, Kv1.2 (KCNA2), Kv2.1 (KCNB1) or Kv4.2 (KCND2). In mice, VaTx3 elicits pain-related behaviors, such as licking and flinching of the affected limb. Edema is evidenced in the paw of toxin-injected mice.  

氨基酸序列：

Glu-Cys²-Arg-Trp-Tyr-Leu-Gly-Gly-Cys⁹-Lys-Glu-Asp-Ser-Glu-Cys¹⁵-Cys¹⁶-Glu-His-Leu-Gln-Cys²¹-His-Ser-Tyr-Trp-Glu-Trp-Cys²⁸-Leu-Trp-Asp-Gly-Ser-Phe-NH₂ 

二硫鍵：Disulfide bonds between Cys²-Cys¹⁶, Cys⁹-Cys²¹ and Cys^15-Cys²⁸ 

長度 (aa)：34  

分子式： C₁₈₄H₂₄₁N₄₇O₅₅S₆ 

分子量：4179.6 Da 

外觀： White lyophilized solid 

可溶性： may be difficult to solubilize 

CAS 號(hào)： not available 

來源：Synthetic 

純度： > 98%

產(chǎn)品信息