Iberiotoxin 伊比(利亞)蝎毒素 

Blocker of high conductance Ca²⁺-activated K⁺ channel

高電導(dǎo)鈣激活鉀離子通道阻斷劑

Iberiotoxin (IbTx) is a toxin that was originally isolated from Buthus tamulus scorpion venom. Iberiotoxin inhibits selectively the high conductance Ca²⁺-activated K⁺ channel (K_Ca1.1) at nanomolar concentrations (IC₅₀ ~2 nM). This toxin does not affect other types of calcium-dependent or voltage-dependent K⁺ channels. Iberiotoxin is a valuable tool to study specifically Maxi-K channels.

Iberiotoxin 技術(shù)資料

氨基酸序列：

pGlu-Phe-Thr-AspVal-Asp-Cys-Ser-Val-Ser-Lys-GIu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-GIn-OH 

二硫鍵：Cys⁷-Cys²⁸, Cys¹³-Cys³³, Cys¹⁷-Cys³⁵ 

長度 (aa)： 37 

分子式：C₁₇₉H₂₇₄N₅₀O₅₅S₇ 

分子量： 4230.8 Da 

外觀：White lyophilized solid 

可溶性：water and saline buffer 

CAS 號(hào)：129203-60-7 

來源：Synthetic  

純度： > 95 %

產(chǎn)品信息