08APA001Apamin(蜜蜂神經毒素)
【簡單介紹】
【詳細說明】
Apamin
Inhibitor of small conductance Ca2+-activated K+ channels
小電導鈣激活鉀離子通道抑制劑
Apamin is a neurotoxin that was originally isolated from Apis mellifera. Apamin binds to and inhibits the SK channels(small conductance Ca2+-activated K+ channels) in the brain and spinal cord. Apamin inhibits three subtypes of SK channels (KCa2.1, KCa2.2, and KCa2.3) with different affinity. Apamin does not affect KCa3.1 channel activity. Apaminmost likely acts as a pore blocker such as Scyllatoxin or Tamapin, although residues both inside and outside of the pore region of the SK channels participate in apamin binding. The SK channels are present in a wide range of excitable and non-excitable cells, including cells in the central nervous system, intestinal myocytes, endothelial cells, and hepatocytes.
Apamin 技術資料
氨基酸序列:
H-Cys1-Asn-Cys3-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys11-Ala-Arg-Arg-Cys15-Gln-Gln-His-NH2
二硫鍵:Cys1-Cys11 and Cys3-Cys15
長度 (aa): 18
分子式: C79H131N31O24S4
分子量:2027.34 Da
外觀: White lyophilized solid
可溶性:water and saline buffer
CAS 號: [24345-16-2]
來源: Synthetic
純度: > 98 %
產品信息
08APA001-00500 | Apamin | 0.5mg |
08APA001-01000 | Apamin | 1mg |
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