百日咳IgG抗體定量酶聯(lián)免疫法檢測試劑盒

英文名稱：Bordela Pertussis IgG (quant.)

廣州健侖生物科技有限公司

（廣州健侖生物科技有限公司是集研制開發(fā)、銷售、服務于一體的優(yōu)良企業(yè),公司產(chǎn)品涉及臨床快速診斷試劑、食品安全檢測試劑，違禁品快速檢測，動物疾病防疫檢測試劑，免疫診斷試劑、臨床血液學和體液學檢驗試劑、微生物檢驗試劑、分子生物學檢驗試劑、臨床生化試劑、有機試劑等眾多領域，同時核心代理Panbio、FOCUS、Qiagen、IBL、CORTEZ、Fuller、Inbios、BinaxNOW、LumuQuick、日本富士、日本生研等多家有名診斷產(chǎn)品集團公司產(chǎn)品，致力于為商檢單位、疾病預防控制中心、海關出入境檢疫局、衛(wèi)生防疫單位,緝毒系統(tǒng)，戒毒中心，檢驗檢疫單位、生化企業(yè)、科研院所、醫(yī)療機構等機構與行業(yè)提供*、高品質的產(chǎn)品服務。此外，本公司還開展食品、衛(wèi)生、環(huán)境、藥品等多方面的第三方檢測服務。）

主要用途：用于定量測定人血清、腦脊液或血漿中的百日咳抗體。

產(chǎn)品規(guī)格：96T/盒

存儲條件：4-8℃

保質期：18個月

【產(chǎn)品介紹】

Pertussis IgG Antibody Quantification Kit (Enzyme-Linked Immunosorbent Assay) For the quantitative detection of anti-pertussis antibodies in human serum and plasma. The reagent can be used for the diagnosis and epidemiological study of acute or recent pertussis infection, while IgG-ELISA reagent is used to monitor the vaccination.

Bordela pertussis belongs to the genus Bordela and is a small globular Gram-negative bacillus. Bordela pertussis is the causative agent of pertussis, a global infectious disease that spreads from person to person through droplets. Babies 0-4 years old are particularly vulnerable to infection. Infants and toddlers have a very high mortality rate High (Infant mortality rate within 1 year old is 60%) 1.

Bordela pertussis is attached to the mucosal ciliated cells of the respiratory tract through its surface ligands. One of the important adhesion proteins is also an important immunogen (antigen), known as Filamentous HemAgglutinin (hereinafter referred to as "FHA"). The synergistic effect of several virulence factors will promote the colonization of bacteria in the respiratory tract and trigger infection.

Bordela pertussis synthesizes and secretes a specific toxin known as Pertussis Toxin (PT), an important virulence factor. Pertussis toxin can produce complex biological effects, such as leukocytosis, lymphocytosis and the body's sensitivity to histamine increased.

A typical pertussis in three stages, after 1-2 weeks of incubation, enters the period of mucosal inflammation (highly contagious), which lasts 1-2 weeks, with a noncharacteristic cough , Rhinitis, and conjunctivitis; the next is the spasm (paroxysmal cough), paroxysmal cough often accompanied by vomiting mucus, laryngospasm and bronchospasm, resulting in infantile bruising, then repeated, sharp Of breath, then continue to cough, severe cases of seizures up to 50 times a day; 4-6 weeks later, the frequency of disease attacks will be reduced and gradually calm down (remission, the duration of up to 6 months).

Infected patients usually produce IgM-, IgA- and IgG-antibodies at the second week of the spasticity (see Figure 1), IgM-antibodies last 2-3 months, and IgA-antibodies rise from the spasm Start for 4-6 months.

IgG-antibodies peak at 6-8 weeks and are detectable until adulthood; IgM- and IgG-antibodies are produced immediay after vaccination; for infants and young children up to 6 months, specific IgM- Antibodies are suitable for the early diagnosis of recent infections, whereas specific IgA-antibodies show better diagnostic properties in infants and young children over 6 months; infants within 3 months do not produce IgA-antibodies.

【檢測原理】

用抗原包被微量板孔，制成固相載體。加患者血清到板孔中，其所含的抗體特異性地與固相載體中現(xiàn)存抗原結合，形成免疫復合物。除去多余物質后，加入結合了堿性磷酸酶的IgG、IgA或IgM抗體，使之與上述免疫復合物反應。洗板，除去多余的結合物，加入底物（對硝基苯磷酸鹽）。其與酶結合的免疫復合物反應，產(chǎn)生有顏色產(chǎn)物，顏色強度與特異性抗體含量成正比。

百日咳IgG抗體定量酶聯(lián)免疫法檢測試劑盒

【試劑盒的組成】

ELISA classic百日咳 IgG: 

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