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solid phase extraction (SPE), coupled to LCMSMS for sample enrichment.

This approach allows for significant and efficient analyte concentration, obviating the need for elaborate and time-consuming sample preparation procedures. Owing to the enrichment, large sample volumes (~ /2 liter) are no longer needed to reach part per trilion levels for estrogen monitoring in river water.

Based on the proven QSight@ LX50 technology, the QSight SP50 Automated Sample Handler一a high-precision UHPLC autosampler - is designed to accurately introduce samples from a variety of vial formats, and coordinate the flow switching required for online SPE. Complementing this, the QSight SP50 High Pressure Dispenser"M (HPD) is responsible for performing the accurate delivery of conditioning, washing, and loading solvents at controlled flow rates at pressures of up to 300 bar. The HPD allows for the selection of up to nine solvents, allowing one to create the optimal sample preparation method. Complete the system with the QSight LX50 solvent delivery module, and the QSight LX50 column temperature module, to create the ultimate high-

performance UHPLC-SPE system.