化工儀器網(wǎng)
資料下載
測(cè)量應(yīng)用案例-20200202
閱讀：172 發(fā)布時(shí)間：2020-2-20| 提 供 商 | 美國(guó)布魯克海文儀器公司 | 資料大小 | 1.4MB |
|---|---|---|---|
| 資料圖片 | 下載次數(shù) | 26次 | |
| 資料類型 | PDF 文件 | 瀏覽次數(shù) | 172次 |
| 免費(fèi)下載 | 點(diǎn)擊下載 |
文獻(xiàn)名： Modulation of membrane properties by DNA in liposomes: A spectroscopic study
作者： Hongjin Qu, Changchun Hao, Zhezhu Nan, Xianggang Zhang, Runguang Sun
School of Physics and Information Technology, Shaanxi Normal University, Xi'an 710062, China
摘要： Liposome mediated DNA transport possesses a number of preventing diseases in clinical trials, thus, the study of interaction between DNA and liposomes has become a hot research direction. In this paper, the adsorption behavior of DNA onto two representative lipids had been studied by the fluorescence spectrum measurement, Ultraviolet absorption spectrum and Langmuir-Blodgett technology. The results of fluorescence spectrum measurement indicated that the fluorescence liposomes were quenched statically by DNA at all three temperatures. Thermodynamic analysis displayed that the intermolecular forces between DNA and liposomes were van der Waals forces and Hydrogen bonding. The experimental results of Ultraviolet absorption spectrum and Langmuir-Blodgett technology further verified these mechanisms. This work provides useful theoretical basis for the development of novel DNA delivery materials.