目錄:MedChemExpress LLC>>信號(hào)通路>> Tivozanib | 替沃扎尼 | MedChemExpress (MCE)
| 參考價(jià) | ￥ 715 |
| 參考價(jià) | ￥ 715 |
更新時(shí)間：2024-01-10 11:18:18瀏覽次數(shù)：93評(píng)價(jià)
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| CAS | 475108-18-0 | 純度 | 99.37% |
|---|---|---|---|
| 分子量 | 454.86 | 分子式 | C??H??ClN?O? |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號(hào) | HY-10977 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)。
CAS No. : 475108-18-0
MCE 國(guó)際站：Tivozanib
產(chǎn)品活性：Tivozanib (AV-951; KRN951) 是一種有效的、選擇性的、具有口服活性的 VEGFR 酪氨酸激酶 抑制劑，對(duì) VEGFR-1、VEGFR-2、VEGFR-3的 IC50 值分別為 0.21、0.16、0.24 nM。Tivozanib 抑制腫瘤組織中的血管生成和血管通透性，并顯示出抗腫瘤活性。Tivozanib 具有研究轉(zhuǎn)移性腎細(xì)胞癌 (RCC) 的潛力。
研究領(lǐng)域：Protein Tyrosine Kinase/RTK
作用靶點(diǎn)：VEGFR
In Vitro: Tivozanib inhibits the phosphorylation of VEGFR-1, VEGFR-2 and VEGFR-3.
In Vivo: Tivozanib (1 mg/kg; p.o.; 14 days) suppresses the development of CNV lesions and leds to a significant regression of established CNV, reducing the affected areas by 67.7%.
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