目錄:MedChemExpress LLC>>信號(hào)通路>> AZD0156 | MedChemExpress
| 參考價(jià) | ￥ 309 |
| 參考價(jià) | ￥ 309 |
更新時(shí)間：2023-09-28 14:55:15瀏覽次數(shù)：104評(píng)價(jià)
聯(lián)系我們時(shí)請(qǐng)說(shuō)明是化工儀器網(wǎng)上看到的信息，謝謝!
| CAS | 1821428-35-6 | 純度 | 99.82% |
|---|---|---|---|
| 分子量 | 461.56 | 分子式 | C??H??N?O? |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 1 mg |
| 貨號(hào) | HY-100016 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)。
CAS No. : 1821428-35-6
MCE 國(guó)際站：AZD0156
產(chǎn)品活性：AZD0156 是一種有效的，選擇性的和口服活性的 ATM 抑制劑，IC50 為 0.58 nM。AZD0156 抑制 ATM 介導(dǎo)的信號(hào)轉(zhuǎn)導(dǎo)，防止 DNA 損傷檢查點(diǎn)激活，破壞 DNA 損傷修復(fù)，并誘導(dǎo)腫瘤細(xì)胞凋亡 (apoptosis)。
研究領(lǐng)域：Cell Cycle/DNA Damage | PI3K/Akt/mTOR | Apoptosis
作用靶點(diǎn)：ATM/ATR | Apoptosis
In Vitro: AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.
相關(guān)產(chǎn)品：Covalent Screening Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | PI3K/Akt/mTOR Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Oxygen Sensing Compound Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Orally Active Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Glucose Metabolism Compound Library | Targeted Diversity Library | Cancer Stem Cells Compound Library | Heterocyclic Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | Serine/Threonine Kinase Inhibitor Library | SY-5609 | BRD4 Inhibitor-18 | 8α-Tigloyloxyhirsutinolide 13-O-acetate | AAPK-25 | Dutasteride-13C6 | Oleic acid-13C | Anticancer agent 120 | Abacavir sulfate | Meloxicam-d3-1 | Thailanstatin D | SB-218078 | Toyocamycin | Sorafenib-d4 | Busulfan | PTC-028 | Dinaciclib | CR-1-31-B | 142I5 | Farudodstat | Ecteinascidin 770 | AT9283 | Staurosporine | SNS-032 | AZA1 | Antitumor agent-96 | Bleomycin A5 | Xevinapant | Mangiferin | Cambinol | hGGPPS-IN-1
熱門(mén)產(chǎn)品線：重組蛋白 | 化合物庫(kù) | 天然產(chǎn)物 | 熒光染料 | PROTAC | 同位素標(biāo)記物 | 寡核苷酸 | 抗體 | 點(diǎn)擊化學(xué)
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
(空格分隔,最多3個(gè),單個(gè)標(biāo)簽最多10個(gè)字符)
會(huì)員.png)
3
化工儀器網(wǎng)