MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務。

WS-383

CAS No. : 2247544-02-9

產(chǎn)品活性：WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC₅₀ of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2.

研究領域：Metabolic Enzyme/Protease

作用靶點：E1/E2/E3 Enzyme

In Vitro: WS-383?(10 μM) is against a panel of kinases such as BTK, CDKs, and EGFR [L858R] using staurosporine and BIBW 2992 as the positive controls. WS-383?showed weak inhibitory activity at 10.0 μM,it is selective to the DCN1-UBC12 interaction over the selected kinasesr.
WS-383 (0.03-3 μM;24 hours)?blocks Cul3 neddylation at 3 μM and also has certain inhibition of Cul1 neddylation at 10 μM but was not effective in inhibiting neddylation of other cullin members.
WS-383 (0.03-3 μM;24 hours)?increases Cul1, Skp1 (adaptor protein), F-box protein, and RBX1/RBX2 RING protein form SCF E3 complex. Cyclin dependent kinase inhibitor 1A (p21) and cyclin dependent kinase inhibitor 1B (p27) expression in a dose-dependent manner in MGC-803 and KYSE70 manner.

相關產(chǎn)品：Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  NF-κB Signaling Compound Library  |  Anti-Cancer Compound Library  |  Oxygen Sensing Compound Library  |  Ubiquitination Compound Library  |  Anti-Liver Cancer Compound Library   |  Heterocyclic Compound Library  |  WSB1 Degrader 1  |  GS143  |  p53 and MDM2 proteins-interaction-inhibitor (racemic)  |  Navtemadlin  |  MX69  |  RG7112  |  MD-224  |  WS-383 free base  |  Ubiquitination-IN-1  |  UbcH5c-IN-1  |  p53-MDM2-IN-1  |  PROTAC MDM2 Degrader-1  |  BC1618  |  C25-140  |  Avadomide  |  RO-5963  |  DCN1-UBC12-IN-2  |  Hinokiflavone  |  SENP1-IN-2  |  Nutlin-3  |  SENP1-IN-1  |  PYR-41  |  SZL P1-41  |  TAK-243  |  NSC624206  |  Cbl-b-IN-1  |  Milademetan  |  Rugonersen  |  Navtemadlin-d₇

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種全球僅有化合物庫，我們致力于為全球科研客戶提供前沿的高品質小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領；
•   產(chǎn)品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產(chǎn)品，廣泛應用于新藥研發(fā)、生命科學等科研項目；
•   提供虛擬篩選，離子通道篩選，代謝組學分析檢測分析，藥物篩選等專業(yè)技術服務；
•   設有專業(yè)的實驗中心和嚴格的質控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質檢報告，確保產(chǎn)品的高純度、高品質；
•   產(chǎn)品的生物活性多經(jīng)各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業(yè)團隊跟蹤最新的制藥及生命科學研究進展，為您提供全球新的活性化合物；
•   與世界各大制藥公司及著名科研機構建立了長期的合作。