| CAS |
931402-35-6 |
供貨周期 |
現(xiàn)貨 |
| 規(guī)格 |
5 mg |
貨號 |
HY-P99006 |
| 應用領域 |
醫(yī)療衛(wèi)生,化工,生物產業(yè),制藥 |
Amatuximab | MCEAmatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium<sup>[1]</sup><sup>[2]</sup>.
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Amatuximab
CAS No. :931402-35-6
產品活性：Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium.
研究領域：Immunology/Inflammation
作用靶點：Mesothelin
In Vitro:Amatuximab (MORAb-009) is a mouse-human chimeric monoclonal antibody with a selective affinity for MSLN. In vitro, amatuximab elicits antibody-dependent cellular cytotoxicity (ADCC) against mesothelin expressing tumor cell lines and inhibits heterotypic cell adhesion of mesothelin-positive tumor cells to CA125-expressing tumor cells.
In Vivo:In tumor xenograft studies, combination treatment with amatuximab plus chemotherapy led to a greater reduction in the growth of mesothelin-expressing tumors than either Amatuximab or chemotherapy alone.
相關產品：Anetumab
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