Monalizumab

MCE 國(guó)際站：Monalizumab

CAS：1228763-95-8

品牌：MedChemExpress (MCE)

存儲(chǔ)條件：Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性：Monalizumab (IPH2201) 是一種靶向自然殺傷細(xì)胞群 2A (NKG2A) 的免疫檢查點(diǎn)抑制劑。Monalizumab 是一種人源化抗 NKG2A 的單克隆抗體，可增加 IFN-γ 產(chǎn)生，從而促進(jìn)自然殺傷細(xì)胞功能。Monalizumab 可用于頭頸部鱗狀細(xì)胞癌 (HNSCC) 的研究。

體外：Monalizumab 阻斷 NKG2A 并增強(qiáng) CLL NK 細(xì)胞介導(dǎo)的針對(duì)表達(dá) HLA-E 的 K562 細(xì)胞的細(xì)胞毒性[3]。Monalizumab 增強(qiáng) Enzalutamide (HY-70002) (10 μM) 誘導(dǎo)的 NK 細(xì)胞活化和殺傷前列腺癌細(xì)胞 (LNCaP 和 22Rv1)[5]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)：Monalizumab (50 μg，瘤內(nèi)注射，與 800 萬(wàn)個(gè)活化的 NK 細(xì)胞一起) 可有效抑制免疫缺陷小鼠異種移植 HLA-E+ 腫瘤的腫瘤生長(zhǎng)[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: immunodeficient mice xenografted with Cal-27 HLA-E high tumor cell[4] Dosage: 50?μg, together with 8?millions of activated NK cells Administration: intratumoral injections Result: Shows a synergestic antitumor effect. Enhanced NK-cell killing, and induces lysis of tumor cells. Clinical Trial

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研究領(lǐng)域：Cell Cycle/DNA Damage  |  Immunology/Inflammation

作用靶點(diǎn)：Checkpoint Kinase (Chk)  |  IFNAR

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參考文獻(xiàn)：

[1]. Thorbald van Hall, et al. Monalizumab: inhibiting the novel immune checkpoint NKG2A. J Immunother Cancer. 2019 Oct 17;7(1):263.[2]. Christian Borel, et al. Immunotherapy Breakthroughs in the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2020 Sep 21;12(9):2691.[3]. McWilliams EM, et al. Therapeutic CD94/NKG2A blockade improves natural killer cell dysfunction in chronic lymphocytic leukemia. Oncoimmunology. 2016 Sep 9;5(10):e1226720.[4]. Melero I, et al. Intratumoral co-injection of NK cells and NKG2A-neutralizing monoclonal antibodies. EMBO Mol Med. 2023 Nov 8;15(11):e17804.[5]. Maximilian Pinho-Schwermann, et al. Androgen receptor signaling blockade enhances NK cell-mediated killing of prostate cancer cells and sensitivity to NK cell checkpoint blockade.doi doi.org/10.1101/2023.11.15.567201