MCE 國(guó)際站:Estradiol
中文名:雌二醇
CAS:50-28-2
品牌:MedChemExpress (MCE)
存儲(chǔ)條件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:雌二醇 (β-Estradiol) 是一種類固醇激素和主要的女性性激素。雌二醇可上調(diào)人子宮內(nèi)膜干細(xì)胞 (hEnSCs) 神經(jīng)標(biāo)志物的表達(dá),促進(jìn)其神經(jīng)分化。雌二醇可用于癌癥、神經(jīng)退行性疾病和神經(jīng)組織工程的研究[1][2]。
體外:Estradiol (10 nM, 7 days) 誘導(dǎo)人子宮內(nèi)膜干細(xì)胞 (hEnSCs) 的神經(jīng)分化和增加軸突分支[1]。
Estradiol (17β-estradiol, 10 nM, 7 days)增加hEnSCs分化的神經(jīng)樣細(xì)胞中神經(jīng)元樣細(xì)胞標(biāo)志物(Tuj-1、巢蛋白和NF-H)的表達(dá)[1]。
體內(nèi):雌二醇(1 nM,來(lái)自 FBN-ARO-KO 小鼠的海馬切片)挽救長(zhǎng)期增強(qiáng) (LTP) 振幅[1]。
雌二醇(0.0167 mg,皮下植入,F(xiàn)BN- ARO-KO 小鼠) 挽救 FBN-ARO-KO 小鼠的分子和功能缺陷[1]。
熱銷產(chǎn)品:HRP-conjugated AffiniPure Goat Anti-Rabbit IgG H&L | Motavizumab | Mirabegron | L-Ascorbic acid (sodium salt) | Larotrectinib | DiZPK | Ciliobrevin D | Citric acid | Dioscin | Neutral protease from paenibacillus polymyxa
研究領(lǐng)域:Vitamin D Related/Nuclear Receptor | Metabolic Enzyme/Protease | Anti-infection
作用靶點(diǎn):Estrogen Receptor/ERR | Endogenous Metabolite | Bacterial
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
參考文獻(xiàn):
[1]. Elham Hasanzadeh. Defining the role of 17β-estradiol in human endometrial stem cells differentiation into neuron-like cells. Cell Biol Int. 2021 Jan;45(1):140-153.
[2]. Yujiao Lu, et al. Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory. J Neurosci. 2019 Apr 10;39(15):2792-2809.
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