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陜西新研博美生物科技有限公司>技術文章>Gd-DTPA\Gd-DOTA造影劑介紹及MRI產(chǎn)品列表價格介紹

技術文章

Gd-DTPA\Gd-DOTA造影劑介紹及MRI產(chǎn)品列表價格介紹

閱讀:6348          發(fā)布時間:2018-10-22

Gd-DTPA\Gd-DOTA造影劑介紹及MRI產(chǎn)品列表價格介紹

核磁共振成像MRI造影劑可以分為縱向弛豫造影劑 (T1制劑)和橫向弛豫造影劑(T2制劑)。T1制劑是通過水分子中的氫核和順磁性金屬離子直接作用來縮短T1,從而增強信號,圖像較亮;T2制劑是通過對外部局部磁性環(huán)境的不均勻性進行干擾,使鄰近氫質(zhì)子在弛豫中很快產(chǎn)生相(diphase)來縮短T2,從而減弱信號,圖像較暗。

弛豫效率是MRI造影劑關鍵指標之一。弛豫效率高的樣品,可以使用少的量達到好的效果;在造影劑研究領域,紐邁專門開發(fā)了小型的核磁共振成像分析儀,可測試方便的測試造影劑T1T2弛豫時間,并可對試管樣品進行成像,提供定量和定性評價數(shù)據(jù),為造影劑產(chǎn)品的研發(fā)與改進提供快速可靠的檢測手段。

目前市面上的T1造影劑產(chǎn)品是Gd釓及Gd的衍生物產(chǎn)品,常用的就是Gd-DTPA釓噴替酸葡甲an。

 

Magnetic resonance imaging (MRI) is an imaging technique usedprimarily in medical research to produce high quality images of in vivosystems. To track materials within in vivo systems, compounds-of-interest aretagged with materials that possess magnetic properties. These materials, aswell as MRI contrast agents, generally fall into two classes. The first issoluble gadolinium compounds that act through the T1 relaxation process and arebrightening agents. The second is particulate iron oxides that act through theT2 relaxation process and are darkening agents. Each type of contrast agent hasits benefits.

 

陜西新研博美生物科技有限公司提供的T1造影劑的產(chǎn)品列表如下:

Gd-DTPA

Gadolinium-Labeled Albumin

Gadolinium-labeled IgG

Gadolinium-labeled Protein A

Gadolinium-labeled Polylysine

Gadolinium-labeled BSA

Gd-BSA-FITC

Gd-BSA-Rhodamine B

Gd-DOTA

Gd-p-SCN-Bn-DOTA

Gd-DO3A-Butylamine

 

DMPE-DTPA-Gd

DTPA-BSA-Gd

DPPE-DTPA-Gd

DSPE-DTPA-Gd

DMPE-DTPA-Gd-DMPE

DPPE-DTPA-Gd-DPPE

DSPE-DTPA-Gd-DSPE

 

陜西新研博美生物科技有限公司可以提供較為齊全的核磁共振成像MRIT1造影劑,詳細產(chǎn)品如下:

產(chǎn)品名稱:Gd-DTPA/Gado-DTPA

產(chǎn)品全稱:Gadolinium-DTPA

中文名稱:2乙3胺五乙酸釓絡合物/釓噴酸葡甲an鹽

外觀:液體

Formula : C28H54GdN5O20

溶劑:0.5 mmol gadopentetatedimeglumine/ml

濃度:469 mg/ml

包裝:10ml

保存時間:4℃,2

廠家:陜西新研博美生物科技有限公司

 

產(chǎn)品名稱:Gd-BSA

產(chǎn)品全稱:Gadolinium-labeledbovine albumin

中文名稱:釓-牛血清白蛋白

產(chǎn)品簡介:

One ml of Galbumin, Trackable Galbumin, orGlowing Galbumin is packaged in a 2 ml sealed serum bottles at a concentrationof 25 mg/ml. Concentrated Galbumin is packaged in a 2 ml sealed serum bottlesat 100 mg/ml. Applications include vascular imaging and injection andinjection-site visualization. Suggested starting dose for rats and mice is 2-4ml/kg.

分子量:66K

外觀:液體

濃度:25 mg/ml

包裝:2ml

保存時間:4℃,2

廠家:陜西新研博美生物科技有限公司

 

產(chǎn)品名稱:Gd-BSA-FITC

產(chǎn)品全稱:Gadolinium-labeledbovine albumin-Fluorescein

中文名稱:釓-牛血清白蛋白-綠色熒光素

外觀:液體

激發(fā)和發(fā)射:490nm-520nm

濃度:25 mg/ml

包裝:2ml

保存時間:4℃,2

用于熒光成像

 

產(chǎn)品名稱:Gd-BSA-RhodamineB

產(chǎn)品全稱:Gadolinium-labeledbovine albumin-Rhodamine B

中文名稱:釓-牛血清白蛋白-紅色羅丹明

外觀:液體

激發(fā)和發(fā)射:570nm-610nm

濃度:25 mg/ml

包裝:2ml

保存時間:4℃,2

用于熒光成像

 

產(chǎn)品名稱:Gd-IgG

產(chǎn)品全稱:Gadolinium-labeled Immunoglobulin G(bovine), Gd-IgG

中文名稱:釓-抗體

介紹:

Gd-IgG is gadolinium-labeled IgG. Thisreagent is engineered to be used as a MRI contrast reagent and is classified asa brightening agent acting through the T1 relaxation process. Gd-IgG is at aconcentration of 25 mg/ml. There are approximately 10 to 15 gadolinium atomsper IgG unit and the molecular weight of the product is approximately 160 kDa.

外觀:液體

濃度:10 mg/ml

包裝:2ml

保存時間:4℃,2

 

產(chǎn)品名稱:Gd-Protein A

產(chǎn)品全稱:Gd-ProteinA, Gadolinium-Protein A

中文名稱:釓-蛋白A

介紹:

Gado-Protein A is gadolinium-labeledProtein A bottled at a concentration of 10 mg/ml. There are approximately 3gadolinium atoms per Protein A unit and the molecular weight of the product is~ 44k Da.

Protein A is a 42 kDa surface proteinoriginally found in the cell wall of the bacterium Staphylococcus aureus. Ithas found use in biochemical research because of its ability to bindimmunoglobulins from many mammalian species. It binds the heavy chain withinthe Fc region of most immunoglobulins and also within the Fab region in thecase of the human VH3 family.

外觀:液體

濃度:25 mg/ml

包裝:2ml

保存時間:4℃,2

 

產(chǎn)品名稱:Gd3O4

產(chǎn)品全稱:Gadoliniumoxide nanoparticles

中文名稱:納米釓氧化物

介紹:

Gadoluminate is the first commerciallyavailable ultra-small gadolinium oxide colloid for use in a wide range of MRIand MRA applications. This product is a 30 nm gadolinium colloid and itprovides a strong T1 brightening signal that is comparable to the same molarconcentration as Gd-DTPA. However, due to its colloidal size and neutralcharge, this reagent is retained in the vascular space. The measured bloodhalf-life (t½) of Gadoluminate in a swine model is approximately 12.5 hours andapproximately 11.9 minutes in a mouse model.

Two ml of Gadoluminate is packaged in a 2ml sealed serum bottles. The product is a 30 nm gadolinium colloid atconcentration of 10 mg Gd/ml.

外觀:液體

粒徑:30納米

濃度:15 mg/ml

包裝:2ml

保存時間:4℃,2

廠家:陜西新研博美生物科技有限公司

 

產(chǎn)品名稱:PLL-Gd

產(chǎn)品全稱:Gadolinium-Polylysine/Gadolinium-labeledpolylysine

中文名稱:聚賴氨酸-

介紹:

Gado-Polylysine is gadolinium-labeledpolylysine. This reagent is engineered to be used as a MRI contrast reagent andis classified as a brightening agent acting through the T1 relaxationprocess. GADOPOLYLYSINE is designed for diffusion studies, for labelingcells, and to allow efficient labeling with ligands, peptides, proteins, andnucleic acid (RNAi, DNA, etc.), wherein a T1 weighted MRI contrast agent isdesired.

外觀:液體

分子量:10k, 22k,50k,110k, 225k

濃度:10 mg/ml

包裝:2ml

保存時間:4℃,2

廠家:陜西新研博美生物科技有限公司

 

產(chǎn)品名稱:Gd-DOTA

產(chǎn)品全稱:Gadolinium-Gadolinium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate

中文名稱: -大環(huán)配體

外觀:粉末

Formula: Gd C??H??N?O?Na·4H?O

FW: 652.7

包裝:500mg/1g

保存時間:-20℃,1

 

Gd-p-SCN-Bn-DOTA

產(chǎn)品名稱:Gd-p-SCN-Bn-DOTA

中文名稱: -大環(huán)配體

外觀:粉末

Formula: GdC??H??N?O?·TFA

FW: 819.9.

純度:94%

包裝:500mg/1g

保存時間:-20℃,1

廠家:陜西新研博美生物科技有限公司

 

產(chǎn)品名稱:14:0PE-DTPA (Gd)DMPE-DTPA-Gd

產(chǎn)品全稱:1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaaceticacid (gadolinium salt)

中文名稱: -大環(huán)配體-磷脂

外觀:粉末

Molecular FormulaC47H90GdN6O17P

Percent CompositionC 47.06%, H 7.56%, Gd 13.11%, N 7.01%, O 22.68%, P 2.58%

Purity>99%

CAS Number827020-81-5

Molecular Weight1199.471

純度:99%

包裝:5mg/10mg

保存時間:-20℃,1

 

產(chǎn)品名稱:DTPA-BSA(Gd)DTPA-BSA-Gadolinium

產(chǎn)品全稱:DTPA-bis(stearylamide)(gadolinium salt)

中文名稱: -大環(huán)配體-牛血清白蛋白

外觀:粉末

Molecular FormulaC50H94GdN5O8

Percent CompositionC 57.16%, H 9.02%, Gd 14.97%, N 6.67%, O 12.18%

Purity>99%

CAS Number186796-30-5

Molecular Weight1050.560

純度:99%

包裝:5mg/10mg

保存時間:-20℃,1

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