美國(guó)Seracare HIV-1血清陽(yáng)轉(zhuǎn)盤(pán)（HIV-1 SC Pnl P） 美國(guó)SeraCare Life Sciences公司主要以血清、血漿等血液制品為主，并在幾年前就收購(gòu)了BBI公司，其產(chǎn)品遠(yuǎn)銷(xiāo)歐洲、亞洲等地方。

美國(guó)Seracare HIV-1血清陽(yáng)轉(zhuǎn)盤(pán)（HIV-1 SC Pnl P）

廣州健侖生物科技有限公司

SeraCare Life Sciences公司主要在美國(guó)、歐洲和亞洲提供促進(jìn)人類(lèi)和動(dòng)物診斷和治療學(xué)的探索、開(kāi)發(fā)和生產(chǎn)的產(chǎn)品和服務(wù)。其業(yè)務(wù)分為兩個(gè)部分：診斷和生物制藥產(chǎn)品和生物服務(wù)。診斷和生物制藥產(chǎn)品部門(mén)生產(chǎn)和銷(xiāo)售診斷和控制面板產(chǎn)品，用于測(cè)試傳染性疾病的臨床實(shí)驗(yàn)室及員工培訓(xùn)和能力測(cè)試。生物服務(wù)部門(mén)提供生物銀行、來(lái)樣加工和測(cè)試服務(wù)。

美國(guó)SeraCare收購(gòu)BBI公司，即原BBI血清盤(pán)已經(jīng)改名為SeraCare血清盤(pán)。

其產(chǎn)品包括有：傳染病陽(yáng)性質(zhì)控品、疾病標(biāo)準(zhǔn)品、細(xì)菌陽(yáng)性質(zhì)控品、人血清白蛋白、人伽馬球蛋白、牛血清白蛋白、血清盤(pán)、人血漿、人血清。

SeraCare的血清盤(pán)包括：HIV-1轉(zhuǎn)化盤(pán)、HIV性能盤(pán)、HBV轉(zhuǎn)化盤(pán)、HBV性能盤(pán)、HCV轉(zhuǎn)化盤(pán)、HCV性能盤(pán)、弓形蟲(chóng)性能盤(pán)、線性盤(pán)和質(zhì)控盤(pán)等等。

我司還提供其它進(jìn)口或國(guó)產(chǎn)試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲(chóng)病、違禁品濫用、肺炎球菌、軍團(tuán)菌、化妝品檢測(cè)、食品安全檢測(cè)等試劑盒以及日本生研細(xì)菌分型診斷血清、德國(guó)SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品。

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美國(guó)Seracare HIV-1血清陽(yáng)轉(zhuǎn)盤(pán)（HIV-1 SC Pnl P）

美國(guó)Seracare 

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【公司名稱(chēng)】 廣州健侖生物科技有限公司

【市 場(chǎng) 部】    楊永漢

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【騰訊Q Q】 2042552662

【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

目前，一些已有的癌癥治療方法需要在實(shí)驗(yàn)室制造抗體與癌細(xì)胞中的蛋白質(zhì)結(jié)合，使其能夠被患者免疫系統(tǒng)摧毀，這個(gè)過(guò)程既耗時(shí)又昂貴。韋斯教授稱(chēng)，他們的發(fā)現(xiàn)可以極大地促進(jìn)抗體的生產(chǎn)效率，而且費(fèi)用會(huì)更少。
該技術(shù)在其他生物技術(shù)領(lǐng)域及食品生產(chǎn)領(lǐng)域也有很大的應(yīng)用價(jià)值。目前，加州大學(xué)歐文分校已經(jīng)為該技術(shù)申請(qǐng)了，并將很快投入市場(chǎng)。
近日，生物學(xué)期刊the journal of BioLogical chemistry在線發(fā)表了來(lái)自美國(guó)科學(xué)家的一項(xiàng)zui近研究成果。研究人員發(fā)現(xiàn)機(jī)體能量水平能夠通過(guò)視黃醇脫氫酶調(diào)控全反式維甲酸的生物合成，通過(guò)實(shí)驗(yàn)證明了全反式維甲酸與胰島素信號(hào)途徑的相互關(guān)系。這一研究成果對(duì)研究胰島素相關(guān)疾病如二型糖尿病等具有一定意義。
全反式維甲酸(atRA)是一種來(lái)自視黃醇(維生素A)的自體有效物質(zhì)，它能夠調(diào)節(jié)能量平衡減少肥胖。Kristin M. Obrochta等人發(fā)現(xiàn)atRA的合成會(huì)受到機(jī)體能量水平的調(diào)節(jié)，這種作用主要是通過(guò)調(diào)節(jié)視黃醇脫氫酶(Rdh)的表達(dá)實(shí)現(xiàn)的。研究人員在給小鼠饑餓再進(jìn)食6小時(shí)后發(fā)現(xiàn)，與饑餓16小時(shí)的小鼠相比，肝臟和棕色脂肪中Rdh1的表達(dá)水平下降了約80%~90%，在肝臟,胰腺和腎臟中Rdh10的表達(dá)下降了約45%~63%，同時(shí)發(fā)現(xiàn)肝臟內(nèi)atRA的表達(dá)水平也下降?？诜咸烟腔蚋骨蛔⑸湟葝u素都會(huì)導(dǎo)致肝臟內(nèi)Rdh1和Rdh10表達(dá)下降50%。
研究人員通過(guò)體外細(xì)胞培養(yǎng)發(fā)現(xiàn)，移除培養(yǎng)基中的血清，會(huì)增加Rdh10和Rdh16(小鼠Rdh1的同源蛋白)表達(dá)，但進(jìn)行胰島素刺激后，Rdh10和Rdh16的表達(dá)水平又發(fā)生下降。通過(guò)對(duì)機(jī)制探討發(fā)現(xiàn)能量水平可以通過(guò)胰島素和Foxo1調(diào)節(jié)Rdh表達(dá)以及atRA的生物合成。

At present, some existing cancer treatment methods require that the antibodies in the laboratory be combined with the proteins in the cancer cells so that they can be destroyed by the patient's immune system. This process is time-consuming and expensive. Professor Weiss said that their discovery can greatly promote the efficiency of antibody production, and the cost will be less.
The technology also has great application value in other areas of biotechnology and food production. Currently, the University of California, Irvine, has applied for a patent for this technology and will soon be on the market.
Recently, the journal of Biological chemistry, an international journal of biological sciences, published a recent research result from American scientists. The researchers found that the energy level of the body can modulate the biosynthesis of all-trans retinoic acid through retinol dehydrogenase, and the relationship between all-trans retinoic acid and the insulin signaling pathway was proved through experiments. This research result has certain significance for the study of insulin-related diseases such as type 2 diabetes.
All-trans retinoic acid (atRA) is an autologous substance derived from retinol (vitamin A) that regulates energy balance and reduces obesity. Kristin M. Obrochta et al. found that the synthesis of atRA is regulated by the body's energy level, which is mainly achieved by regulating the expression of retinol dehydrogenase (Rdh). The researchers found that after 6 hours of starvation and feeding of mice, the expression levels of Rdh1 in liver and brown fat were reduced by about 80% to 90% compared to mice that were hungry for 16 hours, Rdh10 in the liver, pancreas and kidneys. The expression decreased by approximay 45% to 63%, and it was also found that the level of atRA in the liver also decreased. Oral glucose or intraperitoneal injections of insulin all cause a 50% decrease in the expression of Rdh1 and Rdh10 in the liver.
Using in vitro cell culture, the researchers found that removing the serum from the culture medium increased the expression of Rdh10 and Rdh16 (a homolog of mouse Rdh1), but after insulin stimulation, the expression levels of Rdh10 and Rdh16 decreased again. By investigating the mechanism for the discovery of energy levels, Rdh expression and atRA biosynthesis can be regulated by insulin and Foxo1.