美國(guó)Seracare陽(yáng)性血清性能盤（Performance Panels）

廣州健侖生物科技有限公司

SeraCare Life Sciences公司主要在美國(guó)、歐洲和亞洲提供促進(jìn)人類和動(dòng)物診斷和治療學(xué)的探索、開發(fā)和生產(chǎn)的產(chǎn)品和服務(wù)。其業(yè)務(wù)分為兩個(gè)部分：診斷和生物制藥產(chǎn)品和生物服務(wù)。診斷和生物制藥產(chǎn)品部門生產(chǎn)和銷售診斷和控制面板產(chǎn)品，用于測(cè)試傳染性疾病的臨床實(shí)驗(yàn)室及員工培訓(xùn)和能力測(cè)試。生物服務(wù)部門提供生物銀行、來(lái)樣加工和測(cè)試服務(wù)。

美國(guó)SeraCare收購(gòu)BBI公司，即原BBI血清盤已經(jīng)改名為SeraCare血清盤。

其產(chǎn)品包括有：傳染病陽(yáng)性質(zhì)控品、疾病標(biāo)準(zhǔn)品、細(xì)菌陽(yáng)性質(zhì)控品、人血清白蛋白、人伽馬球蛋白、牛血清白蛋白、血清盤、人血漿、人血清。

SeraCare的血清盤包括：HIV-1轉(zhuǎn)化盤、HIV性能盤、HBV轉(zhuǎn)化盤、HBV性能盤、HCV轉(zhuǎn)化盤、HCV性能盤、弓形蟲性能盤、線性盤和質(zhì)控盤等等。

我司還提供其它進(jìn)口或國(guó)產(chǎn)試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團(tuán)菌、化妝品檢測(cè)、食品安全檢測(cè)等試劑盒以及日本生研細(xì)菌分型診斷血清、德國(guó)SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品。

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美國(guó)Seracare陽(yáng)性血清性能盤（Performance Panels）

HIV性能盤、HBV性能盤、HCV性能盤、弓形蟲性能盤、抗EB病毒多價(jià)性能盤、、人類嗜T細(xì)胞病毒I/II型多價(jià)性能盤、巨細(xì)胞病毒多價(jià)性能盤、抗甲肝多價(jià)性能盤、細(xì)小病毒B19多價(jià)性能盤、梅毒性能盤。

美國(guó)Seracare

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【公司名稱】 廣州健侖生物科技有限公司

【市 場(chǎng) 部】    楊永漢

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【騰訊Q Q】 2042552662

【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

APOEε4等位基因是zui常見的阿茲海默癥遺傳風(fēng)險(xiǎn)基因。不過(guò)空氣污染物與阿茲海默癥之間的關(guān)系的卻很少有人注意。而墨西哥城是一個(gè)快速發(fā)展伴隨嚴(yán)重環(huán)境污染的城市，800萬(wàn)城市生活的兒童都不得不每天暴露在PM2.5超標(biāo)的環(huán)境中。為了評(píng)估APOEε4健康兒童在認(rèn)知，嗅覺和代謝性腦指數(shù)方面是否受到空氣污染物影響，研究人員對(duì)50個(gè)生活在墨西哥城市的13.4±4.8歲攜帶APOEε3或者APOEε4的孩子進(jìn)行了韋氏兒童智力量表(WISC-R)評(píng)分和氣味鑒別實(shí)驗(yàn)，同時(shí)用質(zhì)子磁共振測(cè)量海馬，腦橋，額葉頂葉白質(zhì)的腦代謝產(chǎn)物。如預(yù)測(cè)一樣，攜帶APOEε4的孩子右額葉白質(zhì)的關(guān)鍵代謝產(chǎn)物比例比APOEε3的兒童要少，對(duì)肥皂的臭味鑒別困難，言語(yǔ)和智商平分低于平均分，并且顯現(xiàn)出短期記憶和對(duì)關(guān)注的顯著遞減。
研究人員認(rèn)為是持續(xù)暴露于城市空氣污染造成的認(rèn)知不佳，膠質(zhì)細(xì)胞和神經(jīng)元代謝的改變。居住在嚴(yán)重污染的城市，APOEε4的綜合影響可能導(dǎo)致神經(jīng)退行性變化的加速?？諝馕廴臼且粋€(gè)嚴(yán)重的公共衛(wèi)生問題，暴露于空氣中污染物的濃度達(dá)到或超過(guò)現(xiàn)行標(biāo)準(zhǔn)已經(jīng)被證實(shí)與神經(jīng)炎癥和神經(jīng)病理學(xué)相關(guān)。在美國(guó)，有2億人居住在臭氧和細(xì)顆粒物污染物超標(biāo)的環(huán)境中。而且已經(jīng)有證據(jù)顯示顆粒污染物與因中風(fēng)，心血管和呼吸系統(tǒng)疾病的死亡率增加有明顯關(guān)系。而生活在像墨西哥大城市兒童的相關(guān)的健康問題更多。
目前迫切需要有一個(gè)更深入的研究證明APOEε4和空氣污染的相互作用能影響兒童的大腦，或許將來(lái)能提供對(duì)阿爾茨海默氏病的預(yù)防*的新提示。
近日，來(lái)自英國(guó)的科學(xué)家在生物學(xué)期刊molecular and Cellular biology在線發(fā)表了他們關(guān)于RNA聚合酶III調(diào)控巨噬細(xì)胞功能的研究進(jìn)展。
研究人員指出，腫瘤微環(huán)境中的炎癥具有許多促癌癥發(fā)展效應(yīng)。特別是腫瘤相關(guān)巨噬細(xì)胞(TAM)能夠產(chǎn)生許多細(xì)胞因子，促進(jìn)惡性腫瘤細(xì)胞存活，血管生成以及轉(zhuǎn)移維持腫瘤生長(zhǎng)。腫瘤相關(guān)巨噬細(xì)胞內(nèi)細(xì)胞因子的合成與蛋白質(zhì)合成過(guò)程緊密相關(guān)，而蛋白質(zhì)的翻譯過(guò)程又依賴于RNA聚合酶III轉(zhuǎn)錄形成的眾多tRNA。因此研究RNA聚合酶III對(duì)腫瘤相關(guān)巨噬細(xì)胞的功能發(fā)揮有何影響具有重要意義。

The APOEε4 allele is the most common genetic risk factor for Alzheimer's disease. However, little attention has been paid to the relationship between air pollutants and Alzheimer's disease. Mexico City is a rapidly developing city with severe environmental pollution, and 8 million children living in cities have to be exposed to excessive levels of PM2.5 every day. To assess whether APOEε4 healthy children were affected by air pollutants in terms of cognition, olfactory and metabolic brain indices, the researchers performed Wechsler’s inligence on 50 children with APOEε3 or APOEε4 at ages of 13.4±4.8 years living in Mexican cities. Table (WISC-R) scores and odor identification experiments were performed. Proton magnetic resonance was used to measure brain metabolites in the white matter of the hippocampus, pons, and frontal lobe. As predicted, the proportion of key metabolites in the right frontal white matter of children with APOEε4 is lower than that of APOEε3 children. It is difficult to identify soap odors, scores of speech and IQ are lower than average, and short-term memory and attention are shown. Significantly decreasing.
The researchers believe that the continuous exposure to urban air pollution caused poor perception, changes in the metabolism of glial cells and neurons. Living in a heavily polluted city, the combined effects of APOEε4 may lead to an acceleration of neurodegenerative changes. Air pollution is a serious public health problem. Exposure to airborne pollutant concentrations that meet or exceed current standards has been shown to be related to neuroinflammation and neuropathology. In the United States, 200 million people live in environments with excessive ozone and fine particulate matter. Moreover, there has been evidence that particulate pollutants are significantly associated with increased mortality from stroke, cardiovascular and respiratory diseases. There are more health problems related to children living in major cities in Mexico.
There is an urgent need for a more in-depth study to prove that the interaction between APOE ε4 and air pollution can affect children's brains, and may provide new and unprecedented tips for the prevention of Alzheimer's disease in the future.
Recently, scientists from the United Kingdom published their latest research on RNA polymerase III regulating macrophage function in the online journal of molecular and cellular biology.
The researchers pointed out that inflammation in the tumor microenvironment has many cancer-promoting effects. In particular, tumor-associated macrophages (TAMs) are capable of producing many cytokines, promoting the survival of malignant tumor cells, and angiogenesis and metastasis to maintain tumor growth. The synthesis of cytokines in tumor-associated macrophages is closely related to the process of protein synthesis, and the process of protein translation depends on the numerous tRNAs that RNA polymerase III transcribes. Therefore, it is of great significance to study the effect of RNA polymerase III on the function of tumor-associated macrophages.