甲乙型流感病毒分離培養(yǎng)探針檢測(cè)試劑盒

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甲乙型流感病毒分離培養(yǎng)探針檢測(cè)試劑盒

診斷探針，每種診斷探針都有不同的用處及區(qū)別點(diǎn)，共同點(diǎn)都是醫(yī)用品。ALL多探針診斷系統(tǒng)，腸道腺病毒41型診斷探針，應(yīng)用cDNA文庫(kù)法制備HCV-1診斷芯片探針，特異性探針，高靈敏高準(zhǔn)確SARS快速診斷熒光探針等不同產(chǎn)品的使用與方法。
探針1：MYC
8p 染色體的MYC 致癌基因的易位有許多斷裂點(diǎn)，但為了能分別阻斷而不管易位的存在，多探針診斷系統(tǒng)提供的探針組分別探測(cè)的區(qū)域很大(717Kb)。zui接近的探針(177Kb)是332Kb 3'基因，標(biāo)記為紅色。而zui遠(yuǎn)端的探針(188Kb)是380Kb 5'基因，標(biāo)記為綠色。正常病人顯示為融合或紅綠信號(hào)密集地并排(2Y)，同時(shí)，基因的重排檢測(cè)為分開(kāi)的綠色和紅色信號(hào)(1Y,1G,1R)。和分離細(xì)胞一樣，這個(gè)探針組可在間期細(xì)胞中檢測(cè) MYC的重排。
探針2：P16
9p2 染色體缺失牽涉多種腫瘤，包括大約 10%的P16 缺失的兒科 ALL 病人。為了診斷這些缺失，ALL 多探針檢測(cè)系統(tǒng)含一支這樣的探針：標(biāo)記為紅色，覆蓋區(qū)域?yàn)?9p21 101Kb區(qū)域，從P16 3' 59Kb延伸到 P15的 5'端。探針組還包含一支9號(hào)染色體質(zhì)控探針（D9Z3，9q12上異染色質(zhì)的阻斷），標(biāo)記為綠色。正常細(xì)胞中，探針和質(zhì)控在兩者的同系物會(huì)顯示有2個(gè)紅色和2個(gè)綠色信號(hào)(2R，2G)。檢測(cè)細(xì)胞會(huì)顯示：1個(gè)紅色信號(hào)和2個(gè)綠色質(zhì)控(1R，2G)，表明如果缺失為半合子，P16從1條染色體中丟失；或者是沒(méi)有紅色信號(hào)和兩個(gè)綠色信號(hào)（0R，2G），表明是純合子缺失。
探針3：E2A/MLL
E2A 的重排在 ALL病例中相對(duì)普通，有兩種類型（t (1:19) 和 t (17;19)），占病人數(shù)量的 6%。經(jīng)由 FISH檢測(cè)到 E2A相關(guān)的t(1:19)融合，用標(biāo)準(zhǔn)的細(xì)胞遺傳學(xué)檢測(cè)存在20-25%患者遺漏。兩個(gè)分裂探針由1支綠色的 3’探針1支紅色的 5’探針構(gòu)成，基因的缺失將導(dǎo)致黃色或接近的紅/綠的信號(hào)發(fā)生分離，變成單獨(dú)的紅色和綠色。 因而，1個(gè)正常的細(xì)胞有兩個(gè)融合信號(hào)（黃色）。如果 E2A基因因?yàn)橐孜欢嘏?，一支黃色分裂探針?lè)至殉杉t色和綠色，分別代表重排基因和染色體配偶體。這些病人的信號(hào)是3Y、1R、1G。
探針4：/AML1
這種重排在兒童期B-ALL病例中zui普通，使用FISH技術(shù)檢測(cè)到大約21%病例中都有。Cytocell的FISH探針是雙色雙融合探針，陽(yáng)性細(xì)胞有兩個(gè)黃色信號(hào)。 ETV6 ()探針包含一支含ETV6 5’終點(diǎn)的探針和一支覆蓋基因3’區(qū)的探針，都標(biāo)記為紅色。對(duì)于AML，兩支探針都標(biāo)記為綠色，一支位于RUNX1 3'，另一支在基因的5'末端。t(12:21)的病人，除了相應(yīng)的12和21號(hào)正常染色體的紅色和綠色信號(hào)，會(huì)有兩個(gè)（黃色）融合信號(hào)(1R，1G，2Y)。有ETV6有大量缺失的地方，t(12;21)缺失的信號(hào)是1R、2G；或者是，存在t(12;21)重排的信號(hào)是1Y、1G。
探針5：M LL
在染色體區(qū)帶11q23的MLL基因的重排，可以在大約 85%的患B-ALL的嬰兒中發(fā)現(xiàn)。這支分裂探針由一支綠色5’探針和一支紅色3’探針組成，所以基因的破裂會(huì)形成1個(gè)黃色或緊密相連的紅色/綠色信號(hào)分裂成獨(dú)立的紅色和綠色信號(hào)。在正常的細(xì)胞中，會(huì)有2個(gè)融合信號(hào)（黃色）。如果MLL基因因?yàn)橐孜欢嘏?，一支黃色分裂探針?lè)至殉杉t色和綠色，分別代表重排基因和染色體配偶體。這些病人的信號(hào)是1Y,1R,1G。
探針6：BCR/ABL
典型的立體易位t(9;22)在CML中zui普遍，但在大約25% 的成人ALL和2-10% 的小兒ALL也有。BCR基因中有兩個(gè)斷裂點(diǎn)簇，較小和較大的斷裂簇分別為mBCR和MBCR。ALL幾乎大部分是由于斷裂點(diǎn)引起的，包括mBCR。在少量的ALL病例中，因?yàn)榕c其它染色體的相互作用，易位不會(huì)導(dǎo)致細(xì)胞遺傳學(xué)可見(jiàn)的Philadelphia染色體。在這些病例中，F(xiàn)ISH對(duì)于突出融合基因很重要。 診斷系統(tǒng)中的BCR探針是雙融合探針，包含兩支BCR 探針，一支標(biāo)測(cè) BCR 3'，第二支覆蓋了基因5'56Kb的區(qū)域。兩支都標(biāo)記為紅色并定位，所以斷裂點(diǎn)在mBCR或者M(jìn)BCR都可以導(dǎo)致融合信號(hào)。ABL探針毗鄰群從FUB3 基因中部到離ABL 5'終點(diǎn)64Kb的位點(diǎn)，覆蓋了349Kb。 在正常細(xì)胞中，這些探針顯示紅色和綠色信號(hào)，對(duì)應(yīng)各自的同系物（結(jié)果形成了2G 2R的構(gòu)象)。t(9:22)病人，會(huì)有兩個(gè)融合信號(hào)（黃色），加上對(duì)應(yīng)的22號(hào)和 9號(hào)正常染色體的紅色和綠色信號(hào)（1R 1G 2Y）。
探針7：IGH
t(8:14)易位zui顯著的結(jié)果涉及到MYC原癌基因的重排。然而，在T-ALL中zui常見(jiàn)到是IgH基因的非普遍性重排，在B-ALL中也可見(jiàn)到。IGH 基因內(nèi)所有這些重排有斷裂點(diǎn)，Cytocell的 ALL多探針診斷系統(tǒng)中有一支IGH分裂探針，可以檢測(cè)到一些重排，包括固定和變異段之間區(qū)域的 IGH基因分裂，從而鑒別基因中比較少見(jiàn)的重排的IGH易位配偶體染色體。 正常細(xì)胞會(huì)有2個(gè)融合信號(hào)（黃色）。IGH上有重排，其中一個(gè)黃色信號(hào)會(huì)分裂成紅色或黃色（1Y,1R,1G）。

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Diagnostic probes, each diagnostic probe has different uses and differences, the common ground is medical supplies. ALL multi-probe diagnostic system, enteric adenovirus type 41 diagnostic probe, the use of cDNA library preparation of HCV-1 diagnostic chip probes, specific probes, highly sensitive and accurate SARS rapid diagnostic fluorescent probes and other products With method.
Probe 1: MYC
There are many breakpoints in the translocation of the MYC oncogene on the 8p chromosome, but the probe set provided by the multiprobe diagnostic system separay detects large areas (717 Kb) in order to be able to block independently of the presence of translocations. The closest probe (177 Kb) is the 332 Kb 3 'gene, labeled as red. The most distal probe (188 Kb) is the 380 Kb 5 'gene, which is labeled as green. Normal patients are shown as fused or red-green signal-intensive side-by-side (2Y) while gene rearrangement is detected as separate green and red signals (1Y, 1G, 1R). As with cell isolation, this probe set detects MYC rearrangements in interphase cells.
Probe 2: P16
9p2 chromosomal deletion involves a variety of tumors, including about 10% of P16-deficient pediatric ALL patients. To diagnose these deletions, the ALL multi-probe detection system contains one such probe, labeled as red, covering the 9p21 101 kb region, extending from P16 3 '59 kb to the 5' end of P15. The probe set also contains a 9 chromosome-quality control probe (blocking of heterochromatin on D9Z3, 9q12) and is labeled as green. In normal cells, probes and controls show two red and two green signals (2R, 2G) in their homologues. The test cells show one red signal and two green controls (1R, 2G), indicating that P16 is missing from chromosome 1 if the deletion is hemizygous or that there is no red signal and two green signals (0R, 2G ), Indicating a lack of homozygotes.
Probe 3: E2A / MLL
The rearrangement of E2A is relatively common in all cases of ALL, there are two types (t (1:19) and t (17; 19)), accounting for 6% of the patients. E2A-associated t (1: 19) fusion was detected by FISH with 20-25% of patient omissions detected using standard cytogenetics. The two split probes consist of a green 3 'probe and a red 5' probe. Depletion of the gene will cause yellow or near-red / green signals to separate and become red and green separay. Thus, one normal cell has two fusion signals (yellow). If the E2A gene rearranges due to translocation, a yellow split probe splits into red and green, representing the rearranged genes and the chromosome partners, respectively. The signals of these patients are 3Y, 1R, 1G.
Probe 4: / AML1
This rearrangement is most common in childhood B-ALL cases and is detected in approximay 21% of cases using FISH. FISH probes for Cytocell are two-color double-fusion probes, and positive cells have two yellow signals. The ETV6 () probe contains a probe containing the 5 'end of ETV6 and a probe covering the 3' region of the gene, all labeled as red. For AML, both probes are labeled green, one on RUNX1 3 'and one on the 5' end of the gene. Patients with t (12:21) have two (yellow) fusion signals (1R, 1G, 2Y) in addition to the corresponding red and green signals on chromosomes 12 and 21. Where ETV6 is absent in large numbers, the missing signal for t (12; 21) is 1R, 2G; or, the signal for the rearrangement of t (12; 21) is 1Y, 1G.
Probe 5: M LL
MLL gene rearrangement at chromosome region 11q23 can be found in about 85% of infants with B-ALL. The split probe consists of a green 5 'probe and a red 3' probe so that the gene breaks down to form a yellow or closely linked red / green signal split into separate red and green signals. In normal cells, there are 2 fusion signals (yellow). If the MLL gene rearranges due to translocation, a yellow split probe splits into red and green, representing the rearranged genes and the chromosome partners, respectively. The signals for these patients are 1Y, 1R, 1G.
Probe 6: BCR / ABL
Typical stereotactic translocation t (9; 22) is most common in CML, but is also found in approximay 25% of adult ALL and 2-10% of pediatric ALL. There are two breakpoint clusters in the BCR gene, the smaller and the larger breakup clusters are mBCR and MBCR, respectively. ALL is mostly caused by breakpoints, including mBCRs. In a small number of ALL cases, translocations do not result in a cytogenetically visible Philadelphia chromosome because of interactions with other chromosomes. In these cases, FISH is important for highlighting the fusion gene. The BCR probe in the diagnostic system is a double fusion probe that contains two BCR probes, one that maps to the 3 'BCR and the second covers the region of the gene at 5' 56 kb. Both are marked red and positioned, so the breakpoint at mBCR or MBCR can all cause the fusion signal. The ABL probe was adjacent to the cluster from the middle of the FUB3 gene to a 64 kb site 5 'to the ABL, covering 349 kb. In normal cells, these probes display red and green signals corresponding to their respective homologues (resulting in a conformation of 2G2R). t (9:22) The patient will have two fusion signals (yellow) plus the red and green signals for the normal chromosomes 22 and 9 (1R 1G 2Y).
Probe 7: IGH
The most significant result of the t (8:14) translocation involved rearrangement of the MYC oncogene. However, the most common in T-ALL is the non-universal rearrangement of the IgH gene, which is also seen in B-ALL. All of these rearrangements in the IGH gene have breakpoints. In Cytocell's ALL multi-probe diagnostic system there is an IGH cleavage probe that detects rearrangements that include IGH gene disruption in the region between the fixed and mutant segments to identify genes The rare rearranged IGH translocation partner chromosome. Normal cells have two fusion signals (yellow). There are rearrangements on the IGH where one yellow signal splits into red or yellow (1Y, 1R, 1G).