T-bet（T盒子轉錄因子）

廣州健侖生物科技有限公司

T-bet表達于CD4陽性的T淋巴細胞中。T-bet作為成熟T細胞的參考依據(jù)，在Thp中幾乎不表達，在前驅T淋巴細胞白血病中不表達。在反應性淋巴組織如扁桃體、淋巴結和脾臟的濾泡間T細胞區(qū)的分散小淋巴細胞中T-bet表達陽性。T-bet在B細胞淋巴增生性紊亂癥中表達，尤其是B細胞發(fā)育早期，包括前驅B細胞淋巴細胞白血病、成熟B細胞淋巴瘤、邊緣區(qū)淋巴瘤、毛細胞白血病。相反，來源于前生發(fā)中心及生發(fā)中心的B細胞淋巴瘤T-bet陰性。因此，T-bet可以作為B淋巴細胞和T淋巴細胞增生紊亂性疾病的研究及分類標記。

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T-bet（T盒子轉錄因子）

【產品介紹】

細胞定位：細胞漿

克隆號：MRQ-46

同型：IgG

適用組織：石蠟/冰凍

陽性對照：扁桃體/毛細胞白血病

抗原修復：熱修復（EDTA）

抗體孵育時間：30-60min

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

這個科研團隊在研究太陽系水冰的歷史時，重點關注了氫和它的重同位素氘。同位素是同一種元素的不同原子，擁有相同數(shù)目的質子，但中子數(shù)目不同。質量上的差異使得同位素在參與化學反應時出現(xiàn)細微的性質差異。因此，水分子中氫和氘的比率能夠告訴科學家，這些水分子形成時處在怎樣的環(huán)境當中。
舉例來說，星際空間的水冰，氘氫比率就會較高，因為它們形成于極低的溫度。但沒有人知道，在太陽誕生的化學反應中有多少這種富含氘的水會被破壞掉，也沒有人知道，新生太陽系有多大的能力自己產生富含氘的水冰——直到現(xiàn)在。
這個研究團隊建立了模型來模擬原行星盤，其中來自星際空間水冰中的所有氘原子都已經被化學反應清除了，因此這個系統(tǒng)不得不從頭開始，在長達100萬年的模擬時間中，自行生產出含氘的水冰。研究團隊之所以這樣做，是為了弄清楚這樣一個行星系統(tǒng)能不能產生出我們在隕石樣本、地球的海水和“時間膠囊”彗星中看到的那種氘氫比率。結果發(fā)現(xiàn)，他們的模型沒辦法做到這一點——這意味著，我們的太陽系中至少有一部分水起源于星際空間，可以追溯到太陽誕生之前。

The research team focused on hydrogen and its heavy isotope deuterium while studying the history of solar ice and water. Isotopes are different atoms of the same element, with the same number of protons, but different numbers of neutrons. The differences in quality cause subtle differences in the chemical properties of isotopes. As a result, the ratio of hydrogen to deuterium in water molecules ls scientists what environment the water molecules form when they are formed.
For example, in interslar water ice, the hydrogen-to-hydrogen ratio will be higher because they form at very low temperatures. But no one knows how much of this deuterium-depleted water will be destroyed in the chemical reaction to the birth of the sun, and no one knows how much power the nascent solar system can produce its own deuterium-rich water ice - until now.
The team created a model to simulate the protoplanetary disk in which all deuterium atoms from interslar water ice have been chemically removed, so the system has had to start over from a simulated one million years of age, Produce deuterium-containing water ice on your own. The team did this to see if such a planetary system could produce the same deuterium-hydrogen ratio we saw in meteorite samples, the Earth's seawater, and Comet of Time Capsule. The result was that their model did not do that - meaning that at least part of the water in our solar system originated in interslar space, dating back to the birth of the sun.

T-bet is expressed in CD4-positive T lymphocytes. T-bet as a reference for mature T cells, almost no expression in Thp, not expressed in prodromal T-cell leukemia. T-bet expression is positive in scattered small lymphocytes of reactive lymphoid tissue such as the tonsil, lymph nodes, and splenic interfollicular T-cell regions. T-bet is expressed in B-cell lymphoproliferative disorders, especially in the early stages of B cell development, including primed B-cell lymphocytic leukemia, mature B-cell lymphoma, marginal zone lymphoma, and hairy cell leukemia. In contrast, B-cell lymphoma derived from pre-germinal centers and germinal centers is negative for T-bet. Therefore, T-bet can be used as B lymphocytes and T lymphocyte dysplasia research and classification of markers.