PSA 前列腺特異性抗原

廣州健侖生物科技有限公司

PSA是一種由前列腺上皮細(xì)胞合成的33kDa的糖蛋白，目前認(rèn)為具有特異性的腫瘤參考依據(jù)之一，主要用于前列腺癌和轉(zhuǎn)移性前列腺癌的研究。但不能作為良、惡性前列腺疾病的研究，絕大多數(shù)的前列腺增生上皮也呈陽(yáng)性表達(dá)。

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PSA 前列腺特異性抗原

【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞漿

克隆號(hào)：EP-PR8

同型:IgG

適用組織：石蠟/冰凍

陽(yáng)性對(duì)照：前列腺/前列腺癌

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時(shí)間：60min

PSA

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【公司名稱(chēng)】 廣州健侖生物科技有限公司
【市場(chǎng)部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

近日，一項(xiàng)發(fā)表在雜志The JouRNAl of Cell BioLogy上的研究論文中，來(lái)自洛克斐勒大學(xué)的研究人員通過(guò)研究鑒別出了一種信號(hào)通路，其可以刺激棕色脂肪細(xì)胞攝入葡萄糖，或可用于治療2型糖尿病和肥胖。
當(dāng)機(jī)體面對(duì)低溫時(shí)，交感神經(jīng)系統(tǒng)會(huì)激活棕色脂肪細(xì)胞表面的腎上腺受體進(jìn)而刺激棕色脂肪細(xì)胞對(duì)血液中葡萄糖的攝入，隨后棕色脂肪細(xì)胞會(huì)利用葡萄糖作為燃料來(lái)為機(jī)體產(chǎn)熱。葡萄糖的攝入也可以通過(guò)胰島素來(lái)誘導(dǎo)，然而盡管研究人員已經(jīng)揭示了胰島素刺激的葡萄糖攝入，但是腎上腺受體依賴(lài)的葡萄糖攝入的機(jī)制尚不清楚。
這項(xiàng)研究中研究人員通過(guò)對(duì)小鼠進(jìn)行研究發(fā)現(xiàn)，mTORC2信號(hào)通路是棕色脂肪組織腎上腺受體刺激的葡萄糖攝入的關(guān)鍵調(diào)節(jié)子，一種名為mTOR的蛋白激酶參與該過(guò)程，其可以刺激名為GLUT1的葡萄糖入口蛋白向棕色脂肪細(xì)胞表面進(jìn)行運(yùn)輸。研究者Tore Bengtsson教授說(shuō)道，當(dāng)前我們發(fā)現(xiàn)的新型信號(hào)路徑和由胰島素刺激的信號(hào)路徑并不相同，這就意味著棕色脂肪細(xì)胞中的信號(hào)通路很有可能在2型糖尿病患者機(jī)體中處于激活狀態(tài)，而2型糖尿病患者機(jī)體中的胰島素信號(hào)恰恰處于被損傷狀態(tài)。

In a recent research paper published in the international journal The JouRNAl of Cell BioLogy, researchers from the University of Rockefeller have identified, through research, a signaling pathway that stimulates glucose uptake by brown adipocytes or Treatment of type 2 diabetes and obesity.
When the body is exposed to low temperatures, the sympathetic nervous system activates the adrenal receptors on the surface of brown adipocytes to stimulate brown adipocytes' glucose uptake into the bloodstream. Brown adipocytes then use glucose as a fuel to heat the body. Glucose intake can also be induced by insulin, however, although researchers have uncovered insulin-stimulated glucose uptake, the mechanism of adrenergic receptor-dependent glucose uptake remains unclear.
In this study, researchers in the study of mice found that mTORC2 signaling pathway is a key regulator of brown adipose tissue adrenal receptor-stimulated glucose uptake, a protein kinase called mTOR involved in the process, which can stimulate the name The GLUT1 glucose import protein is transported to the surface of brown adipocytes. Researcher Professor Tore Bengtsson said that at present we find that the new signaling pathway and the insulin-stimulated signaling pathway are different, which means that the signaling pathway in brown adipocytes is likely to be activated in the body of type 2 diabetic patients, The insulin signal in the body of patients with type 2 diabetes is precisely in the damaged state.