GATA3 心肌轉(zhuǎn)錄因子3（鼠單克隆抗體）

廣州健侖生物科技有限公司

GATA3是一種鋅指轉(zhuǎn)錄因子，在許多組織中參與激發(fā)、引導(dǎo)細(xì)胞增殖、成長(zhǎng)、分化。但在腫瘤組織中，GATA3排它性地主要在乳腺癌和泌尿道上皮癌表達(dá)。有報(bào)道GATA3在乳腺癌的表達(dá)與ER，PR和Her2有相關(guān)性；在泌尿道上皮癌的表達(dá)與腫瘤的侵潤(rùn)性和級(jí)別呈正相關(guān)。

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GATA3 心肌轉(zhuǎn)錄因子3（鼠單克隆抗體）

【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞核

克隆號(hào)：L50-823

同型：IgG1/K

適用組織：石蠟/冰凍

陽(yáng)性對(duì)照：乳腺癌/尿路上皮癌

抗原修復(fù)：熱修復(fù)

抗體孵育時(shí)間：30-60min

GATA3

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【公司名稱(chēng)】 廣州健侖生物科技有限公司
【市場(chǎng)部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

這項(xiàng)研究意味著人們可以開(kāi)發(fā)出精確的基因療法來(lái)預(yù)防和治療疾病，是高度個(gè)性化醫(yī)療的曙光。個(gè)性化醫(yī)療是非常重要的，因?yàn)槿说膫€(gè)體差異對(duì)疾病發(fā)展影響很大。
CRISPR/Cas9是時(shí)下zui熱門(mén)的基因編輯系統(tǒng)，Cas9蛋白可以說(shuō)是基因工程的瑞士抗原抗體，可以結(jié)合并切割任意DNA。Church等人以一種新方式使用Cas9，讓它激活特定基因的轉(zhuǎn)錄，從而表達(dá)或抑制特定的遺傳學(xué)性狀。他們把Cas9與延長(zhǎng)了三倍的轉(zhuǎn)錄因子融合起來(lái)，使其能夠強(qiáng)力控制單個(gè)或多個(gè)基因的表達(dá)。
“在基因工程領(lǐng)域，能控制遺傳學(xué)性狀的旋鈕越多越好，”Church說(shuō)。“我們展示了一類(lèi)全新的旋鈕，它們可以控制多個(gè)基因，決定特定遺傳學(xué)性狀的表達(dá)或表達(dá)程度?，F(xiàn)在我們可以極為精確的上調(diào)或下調(diào)基因表達(dá)。”研究人員在體外培養(yǎng)的酵母、果蠅、小鼠和人類(lèi)細(xì)胞中證實(shí)了這一技術(shù)操縱基因表達(dá)的能力。
人類(lèi)基因組90%的區(qū)域并不翻譯成蛋白質(zhì)，曾經(jīng)被認(rèn)為是無(wú)用的垃圾。后來(lái)人們發(fā)現(xiàn)，這一區(qū)域的基因以一種神秘的方式起作用，而且這些基因往往串聯(lián)起來(lái)發(fā)揮作用。Church等人開(kāi)發(fā)的新方法，可以靶標(biāo)和激活這些人們知之甚少的DNA暗物質(zhì)。

This research means that people can develop precise gene therapy to prevent and cure diseases, which is the dawn of highly personalized medicine. Personalized medical care is very important, because individual differences in human beings have a great impact on disease development.
CRISPR / Cas9 is the hottest gene editing system of the moment. Cas9 protein is a genetically engineered Swiss antigen antibody that binds and cleaves any DNA. Church et al. Use Cas9 in a new way to activate the transcription of specific genes to express or suppress specific genetic traits. They fused Cas9 with a threefold-longer transcription factor, enabling them to aggressively control the expression of single or multiple genes.
"In genetic engineering, the more knobs that control genetic traits, the better," Church said. "We showed a new class of knobs that control multiple genes and determine the level of expression or expression of specific genetic traits, and we can now very accuray up-regulate or down-regulate them." The researchers studied in vitro yeast The ability of the technique to manipulate gene expression is confirmed in flies, mice and human cells.
Ninety percent of the human genome is not translated into protein and was once considered useless rubbish. It was later discovered that the genes in this area functioned in a mystical way, and these genes tended to work in tandem. The new method developed by Church et al. Targets and activates these poorly understood DNA dark substances.