Cytokeratin 19(細(xì)胞角蛋白19)

廣州健侖生物科技有限公司

該抗體能識(shí)別40KDa的多肽角蛋白19，能與含有CK19的MCF-7細(xì)胞反應(yīng)，不含 CK19的A431 細(xì)胞和HeLa 細(xì)胞不與其發(fā)生反應(yīng)。CK19在肝細(xì)胞中不表達(dá)，因此，該抗體可用于肝臟轉(zhuǎn)移性腫瘤的研究。

細(xì)胞角蛋白19 （CYFRA21-1）細(xì)胞角蛋白是細(xì)胞體的中間絲，根據(jù)其分子量和等電點(diǎn)不同可分為20種不同類型，其中細(xì)胞角蛋白19在肺癌診斷中有很大價(jià)值，是非小細(xì)胞肺癌的重要標(biāo)志物，其為一種相對(duì)分子量40 000、等電點(diǎn)5.2的酸性蛋白，主要分布在單層和假?gòu)?fù)層上皮細(xì)胞。在肺癌的血清濃度閾值為2.2 μg/L，其敏感性、特異性及準(zhǔn)確性分別為57.7%、91.9%和64.9%。從組織學(xué)角度看，鱗癌的敏感性 (76．5%)較腺癌(47．8%)為高，也高于SCC對(duì)兩者的診斷率。細(xì)胞角蛋白19與CEA聯(lián)合應(yīng)用，診斷非小細(xì)胞肺癌符合率已可達(dá)到78%。在宮頸癌、膀胱癌、乳腺癌也有一定的陽(yáng)性率，有報(bào)道稱33%的慢性腎功能衰竭患者CYFRA21-1升高。

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Cytokeratin 19(細(xì)胞角蛋白19)

【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞漿

克隆號(hào)：A53-B/A2.26

同型：IgG1

適用組織：石蠟/冰凍

陽(yáng)性對(duì)照：結(jié)腸癌

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時(shí)間：30-60min

Cytokeratin 19(細(xì)胞角蛋白19)

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【公司名稱】 廣州健侖生物科技有限公司
【市場(chǎng)部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

This antibody recognizes the 40KDa polypeptide keratin 19 and reacts with CK19-containing MCF-7 cells without reaction of CK19-deficient A431 cells and HeLa cells. CK19 is not expressed in hepatocytes, therefore, the antibody can be used for the study of liver metastatic tumors.
Cytokeratin 19 (CYFRA21-1) Cytokeratin is an intermediate filament of a cell body. According to its molecular weight and isoelectric point, it can be divided into 20 different types. Cytokeratin 19 is of great value in the diagnosis of lung cancer. Small cell lung cancer is an important marker, which is a relative molecular weight of 40 000, the isoelectric point of 5.2 acidic protein, mainly in monolayer and pseudostratified epithelial cells. The sensitivity, specificity and accuracy of the serum concentration threshold of 2.2 μg / L for lung cancer were 57.7%, 91.9% and 64.9%, respectively. Histologically, the sensitivity of squamous cell carcinoma (76.5%) was higher than that of adenocarcinoma (47.8%) and higher than that of SCC. Cytokeratin 19 in combination with CEA, diagnostic accuracy of non-small cell lung cancer has reached 78%. In cervical cancer, bladder cancer, breast cancer have a certain positive rate, it has been reported in 33% of patients with chronic renal failure CYFRA21-1 increased.