ALK/p80間變性淋巴瘤激酶（鼠單克隆抗體）

ALK-1

廣州健侖生物科技有限公司

間變性大細(xì)胞淋巴瘤，即是非霍奇金淋巴瘤的一種獨立類型，由德國病理學(xué)家Stein等于1985年應(yīng)用Ki-1（CD30）抗體識別，常呈間變性特征，被命名為間變性大細(xì)胞淋巴瘤。REAL分類將B細(xì)胞表型者歸為彌漫性大B細(xì)胞性淋巴瘤。目前，ALCL只包括T表型和Null（非T非B）表型。約60%-85%左右ALCL病例表達(dá)間變性淋巴瘤激酶（anaplasticlymphomakinase，ALK）融合蛋白，這是由于2號染色體上的ALK基因位點的畸變所致。zui常見的是t（2；5）（p23；q35）而形成融合基因NPM-ALK，它是由位于5號染色體上的核仁磷酸蛋白B23（NPM）基因與位于2號染色體的ALK基因相融合形成，表達(dá)融合蛋白為NPM-ALK蛋白；zui近尚有更多的ALK基因與其他基因通過染色體轉(zhuǎn)位或者是染色體的倒轉(zhuǎn)而形成的融合基因被發(fā)現(xiàn)，如t（1；2）（q25；p23）所形成的TPM3-ALK基因，t（2；3）（p23；q21）產(chǎn)生的TFG-ALKs基因，TFG-ALKL基因和TFG-ALKxL基因，inv（2）（p23；q35）所形成的ATIC-ALK基因，t（2；17）（p23；q23）形成的CLTCL-ALK基因及t（X；2）（q11；p23）形成的-ALK基因。

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【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞漿

克隆號：ALK-1

同型：IgG3/K

適用組織：石蠟/冰凍

陽性對照：間變性大細(xì)胞淋巴瘤

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時間：60min

ALK/p80間變性淋巴瘤激酶（鼠單克隆抗體）ALK-1

臨床表現(xiàn)
阿米巴腸病潛伏期長短不一，自1～2周至數(shù)月以上不等，雖然患者早已受到溶組織內(nèi)阿米巴包囊感染，僅以共棲生存，當(dāng)宿主抵抗力減弱以及腸道內(nèi)感染等臨床上才出現(xiàn)癥狀。根據(jù)臨床表現(xiàn)不同，分為以下類型：
1.無癥狀的帶蟲者
患者雖然受到溶組織內(nèi)阿米巴的感染，而阿米巴原蟲僅作共棲存在，約有90%以上的人不產(chǎn)生癥狀而成為包囊攜帶者。在適當(dāng)條件下即可侵襲組織，引起病變，出現(xiàn)癥狀。
2.急性非典型阿米巴腸病
發(fā)病較緩慢，無明顯全身癥狀，可有腹部不適，僅有稀便，有時腹瀉，每日數(shù)次，但缺乏典型的痢疾樣糞便，大便檢查可發(fā)現(xiàn)滋養(yǎng)體。
3.急性典型阿米巴腸病
起病往往緩慢，以腹痛腹瀉開始，大便次數(shù)逐漸增加，每日可達(dá)10～15次之多，便時有不同程度的腹痛與里急后重，后者表示病變已波及直腸。大便帶血和黏液，多呈暗紅色或紫紅色，糊狀，具有腥臭味，病情較者可為血便，或白色黏液上覆蓋有少許鮮紅色血液?；颊呷戆Y狀一般較輕，在早期體溫和白細(xì)胞計數(shù)可有升高，糞便中可查到滋養(yǎng)體。
4.急性暴發(fā)型阿米巴腸病
起病急劇，全身營養(yǎng)狀況差，重病容，中毒癥狀顯著，高熱，寒戰(zhàn)、譫妄、腹痛、里急后重明顯，大便為膿血便，有惡臭，亦可呈水樣或泔水樣便，每日可達(dá)20次以上，伴嘔吐、虛脫，有不同程度的脫水與電解質(zhì)紊亂。血液檢查中性粒細(xì)胞增多。易并發(fā)腸出血或甩穿孔，如不及時處理可于1～2周內(nèi)因毒血癥而死亡。
5.慢性遷延型阿米巴腸病
通常為急抗原抗體染的延續(xù)，腹瀉與便秘交替出現(xiàn)，病程持續(xù)數(shù)月甚至數(shù)年不愈，在間歇期間，可以健康如常。復(fù)發(fā)常以飲食不當(dāng)、暴飲暴食、飲酒、受寒、疲勞等為誘因，每日腹瀉3～5次，大便呈黃糊狀，可查到滋養(yǎng)體或包囊。患者常伴有臍周或下腹部鈍痛，有不同程度的貧血、消瘦、營養(yǎng)不良等。

ALK/p80間變性淋巴瘤激酶（鼠單克隆抗體）ALK-1

我司還提供其它進口或國產(chǎn)試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細(xì)菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品。

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

Clinical manifestations
The duration of amoebic enteropathy varies in length, ranging from 1 to 2 weeks to several months, although the patient has been infected with Entamoeba histolytica cysts, surviving only in symbionts, diminishing host resistance, and intestinal infections Clinical symptoms before. According to different clinical manifestations, divided into the following types:
Asymptomatic parasites
Although the patient is infected with Entamoeba histolytica, whereas the amoeba is only present as a concentric, about 90% of people do not develop symptoms and become encapsulated carriers. Inappropriate conditions to attack the organization, causing lesions, symptoms.
Acute atypical amoebic enteropathy
Slow onset, no obvious systemic symptoms, may have abdominal discomfort, only loose stools, sometimes diarrhea, several times a day, but the lack of typical dysentery-like stool, stool examination can be found trophozoites.
Acute typical amoebic enteropathy
The onset is often slow to abdominal pain and diarrhea, stool frequency gradually increased daily up to 10 to 15 times as much, then there are varying degrees of abdominal pain and tenesmus, the latter said the lesion has spread to the rectum. Stool blood and mucus, mostly dark red or purple, paste, with stench, the disease may be more for the blood or white mucus covered with a little red blood. Patients with systemic symptoms generally mild, in the early body temperature and white blood cell count may have increased, feces can be found in trophozoites.
4. Acute outbreak of amoebic enteropathy
Severe onset, poor general nutritional status, severe illness, significant symptoms of poisoning, fever, chills, delirium, abdominal pain, tenesmus and severe stools were pus and blood stools, stench can also be water or watery stool, daily up to 20 Times or more, with vomiting, collapse, there are different degrees of dehydration and electrolyte imbalance. Blood tests for neutrophils. Easily complicated with intestinal bleeding or rejection perforation, if not treated in 1 to 2 weeks due to sepsis and death.
5. Chronic persistent amebic enteropathy
Usually the continuation of the acute antigen antibody staining, alternating diarrhea and constipation, the disease lasted months or even years of unhealed, in the intermittent period, can be as normal. Recurrence often to improper diet, overeating, drinking, cold, fatigue and other incentives, daily diarrhea 3 to 5 times, the stool was yellow paste, can be found trophozoites or cysts. Patients often accompanied by umbilical or lower abdominal dull pain, varying degrees of anemia, weight loss, malnutrition and so on.