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品牌 absin
型號(hào) abs171777
廠商性質(zhì) 生產(chǎn)商
所在地 上海市

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CAS	-	純度	-
分子量	-	分子式	-
供貨周期	現(xiàn)貨	規(guī)格	100uL
貨號(hào)	abs171777	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),綜合
主要用途	IHC-P: 1:500

Rabbit anti-CD278/ICOS Recombinant Monoclonal Antibody(R104)，儲(chǔ)存溶液：PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

詳細(xì)介紹

概述
別名	Inducible T-cell costimulator; AILIM
宿主	Rabbit
反應(yīng)種屬	Human
應(yīng)用	IHC-P: 1:500
性能
形式	Liquid
濃度	0.5 mg/ml
純化方法	Protein A affinity column
類型	Monoclonal Antibody
克隆號(hào)	R104
儲(chǔ)存/保存方法	Store at -20℃ for one year.
存儲(chǔ)溶液	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
靶標(biāo)
背景說明	Inducible T cell costimulatory factor (ICOS, cluster of differentiation, CD278) is an activated costimulatory immune checkpoint expressed on T cells. Its ligand ICOSL was expressed in antigen-presenting cells and somatic cells (including tumor cells in the tumor microenvironment) [PMID: 28713380, PMID: 12800259]. As one of the most common targeted immune checkpoints, ICOS is considered a possible way to develop new immunotherapy [PMID: 29544515]. Some clinical studies shown that blocking ICOS alone can inhibit tumor growth and proliferation, as well as TIGIT, CTLA4, and PD-1 [PMID: 30232519, PMID: 28803728].
細(xì)胞定位	Cell Membrane, Secreted
UniProt	Q9Y6W8
實(shí)驗(yàn)結(jié)果圖
	IHC shows positive staining in paraffin-embedded human thymus. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
	IHC shows positive staining in paraffin-embedded human tonsil. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
	IHC shows positive staining in paraffin-embedded human tonsil. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
	Negative control: IHC shows negative staining in paraffin-embedded human kidney. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
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