依魯替尼雜質(zhì)長期備有庫存

時間：2017-2-8閱讀：1626

依魯替尼雜質(zhì)為深圳遠揚化學(xué)技術(shù)有限公司優(yōu)勢雜質(zhì)，長期備有庫存，申報可用，隨貨提供COA證書，氫譜，質(zhì)譜及HPLC，純度符合申報要求，質(zhì)量保證。更多雜質(zhì)對照品，歡迎進入我公司展臺查詢。

依魯替尼作用機理：依魯替尼是一種小分子BTK抑制劑，能夠與BTK活性中心的半胱氨酸殘基共價結(jié)合，從而抑制其活性。BTK全稱Bruton'styrosinekinase，在BCR信號通路、細胞因子受體信號通路中傳遞信號，介導(dǎo)B細胞的遷移、趨化、粘附。臨床前研究證明，依魯替尼能夠抑制惡性B細胞的增殖、生存。臨床試驗：111例既往至少接受過一項治療的患者經(jīng)依魯替尼治療后，總應(yīng)答率為65.8%（*應(yīng)答17.1%+部分應(yīng)答48.6%），中位持續(xù)應(yīng)答時間為17.5個月。

附：深圳遠揚化學(xué)提供依魯替尼雜質(zhì)庫存列表：

若列表中無您需要的雜質(zhì)，詳詢，我司可提供依魯替尼雜質(zhì)定制服務(wù)。

Ibrutinib	(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Ibrutinib Impurity 1	(S)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Ibrutinib Impurity 2	(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
Ibrutinib Impurity 3	(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-chloropropan-1-one
Ibrutinib Impurity 4	(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethanone
Ibrutinib Impurity 5	1,3-bis((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
Ibrutinib Impurity 6	3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Ibrutinib Impurity 7	(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Ibrutinib Impurity 8	(R)-tert-butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Ibrutinib Impurity 9	1-((R)-3-(4-((3-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)amino)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Ibrutinib Impurity 10	(R)-N-(1-(1-acryloylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)acrylamide

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依魯替尼雜質(zhì)長期備有庫存

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