匹伐他汀雜質(zhì)列表  深圳遠揚化學(xué)技術(shù)有限公司主營醫(yī)藥標準品及雜質(zhì)對照品，以下雜質(zhì)備有庫存，可當(dāng)天發(fā)貨，*：匹伐他汀雜質(zhì)，曲氟尿苷雜質(zhì)，依魯替尼雜質(zhì)，奧貝膽酸雜質(zhì)，依美斯汀雜質(zhì)，卡格列凈雜質(zhì)，利格列汀雜質(zhì)，西格列汀雜質(zhì)，埃索美拉唑雜質(zhì)，LCZ696雜質(zhì)，恩雜魯胺雜質(zhì)，艾曲波帕雜質(zhì)，非布司他雜質(zhì)，托匹司他雜質(zhì)，樂伐替尼雜質(zhì)，奧拉帕尼雜質(zhì)，阿維巴坦雜質(zhì)，奧美拉唑雜質(zhì)，普卡必利雜質(zhì)，西他沙星雜質(zhì)，泊沙康唑雜質(zhì)，替格瑞洛雜質(zhì)，托法替尼雜質(zhì)，決奈達隆雜質(zhì)，阿奇霉素雜質(zhì)等。

匹伐他汀鈣背景及前程：

冠心病是威脅人類健康和生命的常見病和多發(fā)病，以低密度脂蛋白(LDL)升高為特征的高膽固醇血癥則是誘發(fā)冠心病的主要危險因子之一。常用的降血脂藥如煙酸類、樹脂類或貝特類等療效都難盡人意，降脂作用的是被稱為他汀類(statins)的藥物。他汀類藥物共同的作用機制是都屬于3—羥—3—甲基—戊二酰輔酶A(HMG—CoA)還原酶抑制劑，目前在世界廣泛應(yīng)用的主要有6種：洛伐他汀(lovastatin)，普伐他汀(pravastatin)，辛伐他汀(simvastatin)，西立伐他汀(cerivastatin)，氟伐他汀(fluvastatin)和阿托伐他汀(atorvastatin)。而近期由Kowa公司開發(fā)的新型他汀類藥物匹他伐他汀鈣，因其良好的降膽固醇作用而被稱為“超級他汀類藥物”(Superstatin)。

匹伐他汀雜質(zhì)列表（具體結(jié)構(gòu)式見附件）

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Pitavastatin

(+)-Monocalcium bis{(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate}

Pitavastatin Impurity 1

(3R,6E)-7-[2-cyclopropyl-4-(4-flurophenyl)-3-quinolinyl]-3-hydroxy-5-oxo-6-heptenoate

Pitavastatin Impurity 2

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid calcium salt

Pitavastatin Impurity 3

(4R,6S,E)-6-[2-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl] vinyl] tetrahydro-4-hydroxypyran-2-one

Pitavastatin Impurity 4

7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid

Pitavastatin Impurity 5

(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid calcium salt

Pitavastatin Impurity 6

(3S,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid calcium salt

Pitavastatin Impurity 7

(3R,5S,6E)-7-[2-Cyclopropyl-4-phenyl-quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid calcium salt

Pitavastatin Impurity 8

 [[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenyl-phosphonium Bromide

Pitavastatin Impurity 9

(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-2,2-dimethyl-1,3-dioxane-6-heptenoic acid t-butyl ester

Pitavastatin Impurity 10

(3R,5S,E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxy-N-(1-phenylethyl)hept-6-enamide

Pitavastatin Impurity 11

Sodium (5S, 6E)-7-[2-cyclopropyl-4-(4-flurophenyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate

Pitavastatin Impurity 12

Ethyl (3R, 6E)-7-[2-cyclopropyl-4-(4-flurophenyl)-3- quinolinyl]-3-hydroxy-5-oxo-6-heptenoate

Pitavastatin Impurity 13

Ethyl (5S, 6E)-7-[2-cyclopropyl-4-(4-flurophenyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate

Pitavastatin Impurity 14

(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid methyl ester

Pitavastatin Impurity 15

(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid ethyl ester

Pitavastatin Impurity 16

(3R,5S)-5-(6-Cyclopropyl-10-fluoro-7,8-dihydrobenzo[k]phenanthridin-8-yl)-3,5-dihydroxypentanoic acid sodium salt

Pitavastatin Impurity 17

2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinemethanol

Pitavastatin Impurity 18

(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid ethyl ester

Pitavastatin Impurity 19

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid ethyl ester

Pitavastatin Impurity 20

(3S,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid ethyl ester

Pitavastatin Impurity 21

(3R,5S,6E)-7-(2-Cyclopropyl-4-phenyl-3-quinolinyl)-3,5-dihydroxy-6-heptenoic Acid tert-Butyl Ester

Pitavastatin Impurity 22

2-((4R,6S)-6-((E)-2-(2-Cyclopropyl-4-phenylquinolin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic Acid tert-Butyl Ester