人凝血因子XIa（Human Factor XIa）HFXIa 1111a 說明書

最近更新時(shí)間：2013-7-12

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 Enzyme Research ，Enzyme Research 介紹,Enzyme Research 代理,Enzyme Research 總代,Enzyme Research *代理,Enzyme Research 中國代理

Enzyme Research 是一家擁有超過25年的酶研究的實(shí)驗(yàn)室，生產(chǎn)和開發(fā)多種用于基本凝血研究的多種酶和輔因子。在過去的十年Enzyme Research Laboratories為科學(xué)家參與止血和血栓形成的研究提供了寶貴支持。Enzyme Research通過不斷追求產(chǎn)品的zui高品質(zhì)，贏得了世界各地凝血研究實(shí)驗(yàn)室的信任。

Human Factor XIa

HFXIa 1111a             Human Factor XIa

Prepared from Human Factor XI using Human Factor Xlla. This Xlla was removed using a corn trypsin inhibitor column. Complete activation is observed by SDS-PAGE. Factor XI, through the contact factor pathway cascade, is activated to Factor XIa via Factor Xlla and High Molecular Weight Kininogen. During activation by Factor Xlla and HK, FXI undergoes proteolytic cleavage in which the Mr=80,000 chain reportedly is cleaved to a heavy and light chain with Mr of about 48,000 and 33,000. This Factor XIa is responsible for the activation of Factor IX to Factor IXa. Unlike other examples of activation of Vitamin K-dependent blood-clotting proteins, Factor XIa proteolysis of Factor IX does not require membrane surfaces.

Buffer composition = 4 mM Sodium Acetate-HCl/0.15 M NaCl/pH 5.3
*Extinction Coefficient （1%） = 13.1
Molecular Weight = 160,000 daltons

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