PQ401 196868-63-0

 PQ-401
分子式：C18H16ClN3O2   分子量：341.79
 
產品描述
PQ401抑制IGF-1R區(qū)域自磷酸化，IC50為<1 μM。
靶點
IGF-1R
         
IC50
<1 μM
         
體外研究
PQ 401 is an IGF-1R inhibitor and inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1μM. PQ 401 significantly reduced proliferation of MCF-7 cells with IC50 of 8 μM. PQ 401 also inhibits growth of MCNeuA cells with IC50 of 15 μM. PQ 401 inhibits the IGF-I-mediated antiapoptotic pathway in MCF-7 cells. PQ 401 increases caspase-mediated apoptotic activity in MCF-7 cells.
體內研究
PQ 401 (50 mg/Kg, 100 mg/Kg) significantly inhibits MCNeuA tumor growth in a dose-dependent manner.
溶解性
DMSO 50 mM ，乙醇 25 mM
穩(wěn)定性
2年 -20°C粉狀，6月-80°C溶于DMSO