Buclizine HCl 129-74-8鹽酸安其敏，鹽酸布可立嗪

鹽酸安其敏，鹽酸布可立嗪
分子式：C28H33ClN2.2HCl   分子量：505.95
 
產(chǎn)品描述
Buclizine HCL是哌qin衍生物家族的antihistamine（抗組胺藥） 和anticholinergic（抗膽堿藥）。
靶點(diǎn)
           
IC50
           
體外研究
Buclizine hydrochloride, a piperazine derivative, is a sedating antihistamine with antimuscarinic and moderate sedative action. Buclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which buclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects.
體內(nèi)研究
 
溶解性
DMSO 0.2 mg/mL，水 <1 mg/mL，乙醇 <1 mg/mL
穩(wěn)定性
2年 -20°C粉狀，6月-80°C溶于DMSO