Liver-Chip肝臟芯片現(xiàn)貨， Emulate, Inc， LIVER BIO-KIT

授權(quán)代理，現(xiàn)貨供應(yīng)，

Model Overview

Our Liver-Chip recreates true-to-life functions of the liver and is available in three different cell configurations: co-culture, tri-culture, and quad-culture. Our human Liver-Chip incorporates relevant extracellular matrix (ECM) interactions, a hepatocyte and liver sinusoidal endothelial cell interface, along with relevant cyto-architecture, and physiological flow.

Configurations

Our Human Liver-Chip can be set up into various configurations using our approved protocols, depending on study requirements — including co-, tri-, and quad-culture.

Co-Culture

hepatocytes + LSECs

Tri-Culture

Co-Culture + Kupffer cells

Quad-Culture

Tri-Culture + stellate cells

Applications

Our Liver-Chip demonstrates in vivo-relevant responses to known and tool compounds at clinically relevant concentrations and through the appropriate mechanisms of action.

General Toxicity · Mechanistic Toxicity · Nutrient Metabolism

LIVER BIO-KIT

Our Human Liver-Chip is currently available as a complete kit including Organ-Chips, cells, reagents, training, and support from our team of experts. For more information about kit options and pricing, contact us below.

LIVER SERVICES

We offer services run on our Liver-Chips to deliver clinically-relevant, decision-worthy insights. Our experienced services team is ready to design and execute studies with your desired endpoints in mind.

Resources

PUBLICATIONS

Reproducing Human and Cross-Species Drug Toxicities Using a Liver-Chip

Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans, contributing to drug failures in the clinic. Here, we applied microengineered Organs-on-Chips technology to design a rat, dog, and human Liver-Chip….

Nov 6, 2019

PROTOCOLS

Protocols developed by our experts guide the process of Liver-Chip culture and analysis.