GLS4 莫非賽定 Morphothiadin
- 公司名稱 MedChemExpress LLC
- 品牌 MedChemExpress (MCE)
- 型號 GLS4
- 產(chǎn)地
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時間 2019/6/27 8:50:13
- 訪問次數(shù) 714
聯(lián)系我們時請說明是化工儀器網(wǎng)上看到的信息，謝謝!
MedChemExpress (MCE) 專注于為科學家提供高品質(zhì)的生物活性小分子化合物，化合物庫及各類試劑盒，總部位于美國新澤西。
• MedChemExpress (MCE) 產(chǎn)品作用于 20 多個熱門信號通路及研究領(lǐng)域的300多個細分靶點，擁有 10000 特異性抑制劑、激動劑，以及 50 活性化合物篩選庫；
• 我們堅持對所有產(chǎn)品進行嚴格質(zhì)檢，確保產(chǎn)品的高品質(zhì)和高純度；
• MedChemExpress (MCE) 產(chǎn)品已被數(shù)萬名科學家信賴，并被大量top文獻和*引用；
• 我們擁有專業(yè)的技術(shù)團隊追蹤前沿科研進展，不斷豐富各個靶點的特異性產(chǎn)品，堅持做 “您身邊的抑制劑大師”；
• MedChemExpress (MCE) 與眾多藥企和科研機構(gòu)保持深度合作；
• 大量產(chǎn)品有中國庫存，工作日 16:00 前訂單確保當日發(fā)貨，次日送達。
MCE 中國站：www.MedChemExpress.cn
Hotline: 400-820-3792
Tel: 021-58955995
Email: sales@MedChemExpress.cn
Tech Support: 021-58950656
抑制劑，調(diào)節(jié)劑，API，天然產(chǎn)物，各種類型化合物庫
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL；1 mg；5 mg；10 mg；25 mg；50 mg |
|---|---|---|---|
| 貨號 | HY-108917 | 應用領(lǐng)域 | 生物產(chǎn)業(yè) |
Morphothiadin
產(chǎn)品活性：Morphothiadin 是野生型和阿德福韋耐藥 HBV 復制的有效抑制劑，其 IC50 值為 12 nM。
研究領(lǐng)域：Anti-infection
作用靶點：HBV
In Vitro: Morphothiadin is a potent inhibitor on the replication of both wild-type and adefovir-resistant HBV with an IC50 of 12 nM. Morphothiadin (GLS4) shows no toxicity up to 25 μM. The cytotoxic dose whereby 50% of cells die (CC50) for primary hepatocytes is 115 μM for Morphothiadin (P<0.001). The CC90 is 190 μM for Morphothiadin (P<0.01) in HepAD38 cells. Morphothiadin strongly inhibits virus accumulation in the supernatant of HepAD38 cells at 25 nM to 100 nM (P<0.02). Results show a concentration-dependent decrease of core protein in cells treated with Morphothiadin.
In Vivo: The area under the concentration-time curve from 0 to 24 h (AUC0-24) of Morphothiadin (GLS4) is 556 h?ng/mL. After intravenous administration of 10 mg/kg Morphothiadin, the total plasma clearance and apparent volume distribution are 4.2 liters/h/kg and 7.38 liters/kg, respectively. The bioavailability of Morphothiadin is 25.5%. It is found that virus titers have increased 83.5-fold in mice treated with 3.75 mg/kg per day of Morphothiadin, 28.3-fold among mice treated with 7.5 mg/kg per day, but only 3- to 6-fold among mice treated with the higher doses of Morphothiadin. There is generally an inverse relationship between Morphothiadin dose and virus titer, with the greatest rebound seen in mice treated with 3.75 mg/kg per day of Morphothiadin (540-fold) and the smallest rebound in mice treated with 60 mg/kg per day (23-fold) (P<0.001). The Morphothiadin doses of >7.5 mg/kg per day significantly suppresses the virus replication cycle throughout the treatment period, while Morphothiadin doses of >15 mg/kg per day suppresses virus for up to 2 weeks after the end of treatment.
相關(guān)產(chǎn)品：Drug Repurposing Compound Library | Anti-Infection Compound Library | Anti-Virus Compound Library | Clinical Compound Library | Clinical Compound Library Plus | Drug Repurposing Compound Library Plus | Bioactive Compound Library Plus | Bay 41-4109 | Entecavir monohydrate | Tenofovir Disoproxil Fumarate | Adefovir dipivoxil | Squalamine | AB-423 | Merimepodib | JNJ-632 | Bicyclol | Inarigivir | RIG-1 modulator 1 | Oxethazaine | Telbivudine | RG7834 | Clevudine | Osalmid | Helioxanthin derivative 5-4-2 | BA-53038B | Helioxanthin 8-1 | Hepatitis B Virus Core 128-140 | Lagociclovir
采購中心
化工儀器網(wǎng)