動物實驗低壓氧艙用于模擬低壓氧環(huán)境，氧氣濃度可自動控制，解決了艙體內(nèi)氧濃度的自動控制問題，同時氣體濃度在艙體內(nèi)更均勻，適用于中小型動物如犬、猴、兔、鼠等。

由動物艙體、氣體輸送控制系統(tǒng)、環(huán)境監(jiān)測系統(tǒng)、視頻監(jiān)測功能、溫控系統(tǒng)等構(gòu)成。通過調(diào)節(jié)動物艙內(nèi)氧氣（或空氣）和氮氣的混合比例，間接控制氧氣濃度的效果；氧氣濃度的大小以及維持低氧環(huán)境的時間，均由中央處理器自動控制，設(shè)備的自動化程度高，無須專人守候；流量計、分布器以及緩沖罐的使用，減小甚至消除了細股急流氣體對小動物的影響，具有供氣均勻、平緩的優(yōu)點，從源頭上消除了動物艙氧濃度分布不均勻的現(xiàn)象。

功能及特點

1.確保安全

從設(shè)計開始到zui終完成測試和檢查，所有實驗氧艙都遵循嚴(yán)格的生產(chǎn)過程；

具有緊急關(guān)閉和自動排氣系統(tǒng)，以適應(yīng)各種情況。

2.動物艙體

ProOx-810 動物實驗低壓氧艙主體采用進口亞克力加厚材質(zhì)，堅固可靠，透明方便觀察；

鋁合金及不銹鋼材料支撐；

具有腳輪腳剎設(shè)計，方便移動。

3.氣體輸送控制系統(tǒng)

醫(yī)用級靜音高壓泵及低壓泵，為系統(tǒng)提供穩(wěn)定的壓力；

4.整體管路采用防爆管，抗壓強；

具有氣體緩沖器，減小甚至消除了細股急流氣體對小動物的影響；

多級空氣過濾器確保空氣來源清潔，消除碳氫化合物可能引起的火災(zāi)危險；同時去除空氣供應(yīng)中的微粒物質(zhì)、水分、油和油蒸氣。

5.自動控制氧濃度及維持氧濃度的持續(xù)時間。

實驗監(jiān)測、控制、報警

監(jiān)測參數(shù)：艙體內(nèi)溫度、濕度、壓力、氧氣濃度、二氧化碳濃度監(jiān)測

控制參數(shù)：艙體內(nèi)的溫度、濕度、壓力、氧氣濃度、氧濃度維持時間

報警參數(shù)：溫度上限、溫度下限、壓力上限、壓力下限、氧濃度上限、氧濃度下限

6.動物生理指標(biāo)監(jiān)測

監(jiān)測指標(biāo)（選配）：心電圖、體溫、血壓、呼吸、血氧飽和度

具有擴展接口，用于靜脈注射、采血、血壓監(jiān)測等

7.視頻監(jiān)測功能

配備視頻采集卡及攝像頭，可錄像拍照

8.溫控系統(tǒng)

具有動物恒溫平臺，溫度可控制

采用水循環(huán)恒溫機制，防止電加熱過程在高氧環(huán)境中潛在的危險

使用客戶名單

相關(guān)文獻

[1]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia.[J] International Journal of Pharmaceutics,2020,591

?[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang.Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling.[J]Archives of Biochemistry and Biophysics ,Volume 729, 109393;

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[8]Zhang, C., Sun, Y., Guo, Y. et al. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension. “[J].Cell Death Discov. 9, 98 (2023).

[9]Zhang, L., Liu, X., Wei, Q. et al. “Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p. “[J]. Mamm Genome 34, 76–89 (2023).

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[11]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia" . [J] International Journal of Pharmaceutics,2020,591

[12]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner" . [J]. European Journal of Pharmacology,Renal Failure, 44:1, 2056-2065

[13]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling" . [J]. Biomedicine & Pharmacotherapy, Volume 156, 2022,113982

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[15]Wan-ping Yang, Mei-qi Li, Jie Ding, Jia-yan Li, Gang Wu, Bao Liu, Yu-qi Gao, Guo-hua Wang, Qian-qian Luo. "High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen.” [J]. bioRxiv preprint, 2023.03.23.533972

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[17]Liu,J,Peng, S,Ye,L, Sun, Y, Zhao, Q, Wei, H, Luo, Q, He M, & Wang, G(2023).“ Neuroinflammation aggravated by traumatic brain injury at high altitude is reversed by L-serine via NFAT1-mediated microglial polarization.”[J]. Frontiers in Cellular Neuroscience, 17, 1152392. doi: 10.3389/fncel.2023.1152392

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